Evidence map›Paper›PMID 21197654›Full record

ReviewWiley interdisciplinary reviews. Systems biology and medicine

Influenza A virus infection kinetics: quantitative data and models.

Amber M Smith, Alan S Perelson

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed.

  1. Article
  2. Article
  3. A non-canonical role ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Spatially structured models of viral dynamics: a scoping review.Microbiology and molecular biology reviews : MMBR · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amber M SmithTheoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA.
Alan S Perelson

Funding

Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
MODELING VIRAL AND T LYMPHOCYTE DYNAMICSR01RR006555 · NCRR · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1991 to 2011
$3.9M
Immune System Modeling/HIVR01AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 1990 to 2021
$3.7M
Immune System Modeling/HIVR37AI028433 · NIAID · UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB · PI PERELSON, ALAN S · 2002 to 2011
$2.4M
NCRR NIH HHS R01 RR006555NCRR NIH HHS RR06555NIAID NIH HHS AI28433NIAID NIH HHS N01 AI050020NIAID NIH HHS N0I-AI50020NIAID NIH HHS R01 AI028433NIAID NIH HHS R37 AI028433NIH HHS R01 OD011095
6 · The paper itself

Abstract

Influenza A virus is an important respiratory pathogen that poses a considerable threat to public health each year during seasonal epidemics and even more so when a pandemic strain emerges. Understanding the mechanisms involved in controlling an influenza infection within a host is important and could result in new and effective treatment strategies. Kinetic models of influenza viral growth and decay can summarize data and evaluate the biological parameters governing interactions between the virus and the host. Here we discuss recent viral kinetic models for influenza. We show how these models have been used to provide insight into influenza pathogenesis and treatment, and we highlight the challenges of viral kinetic analysis, including accurate model formulation, estimation of important parameters, and the collection of detailed data sets that measure multiple variables simultaneously. WIREs Syst Biol Med 2011 3 429-445 DOI: 10.1002/wsbm.129

Indexed as

Models, BiologicalAntiviral AgentsHumansInfluenza A virusInfluenza, HumanInterferonsKineticsAntiviral AgentsInterferons

Identifiers

PMID21197654
PMCPMC3256983

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.