ReviewWiley interdisciplinary reviews. Systems biology and medicine
Genome-wide approaches in the study of microRNA biology.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Cancer cell-derived exosomal miR-20a-5p inhibits CD8Cancer science · 2024Article
- LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p/CCR7 axis.3 Biotech · 2024Article
- miR-182-5p Serves as an Oncogene in Lung Adenocarcinoma through Binding to STARD13.Computational and mathematical methods in medicine · 2021Article
- Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of miRNA-eQTLs in maize mature leaf by GWAS.BMC genomics · 2020Article
- miR-148a and miR-17-5p synergistically regulate milk TAG synthesis via PPARGC1A and PPARA in goat mammary epithelial cells.RNA biology · 2017Article
- A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas.Oncotarget · 2014Article
- mirMark: a site-level and UTR-level classifier for miRNA target prediction.Genome biology · 2014Article
- Accuracy of microRNA discovery pipelines in non-model organisms using closely related species genomes.PloS one · 2014Article
- MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma.The Journal of biological chemistry · 2013Article
- Systematic analysis of genomic organization and heterogeneities of miRNA cluster in vertebrates.Molecular biology reports · 2012Article
- MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells.PloS one · 2012Article
- Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways.PloS one · 2012Article
- Genome-wide approaches to dissect the roles of RNA binding proteins in translational control: implications for neurological diseases.Frontiers in neuroscience · 2012Article
- Bioinformatic challenges of big data in non-coding RNA research.Frontiers in genetics · 2012Article
- Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications.Genetics research international · 2012Article
- Tiny giants of gene regulation: experimental strategies for microRNA functional studies.Wiley interdisciplinary reviews. Developmental biologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
MicroRNAs (miRNAs), a class of ∼21-23 nucleotide long non-coding RNAs (ncRNAs), have critical roles in diverse biological processes that encompass development, proliferation, apoptosis, stress response, and fat metabolism. miRNAs recognize their target mRNA transcripts by partial sequence complementarity and collectively have been estimated to regulate the majority of human genes. Consequently, misregulation of miRNAs or disruption of their target sites in genes has been implicated in a variety of human diseases ranging from cancer metastasis to neurological disorders. With the development and availability of genomic technologies and computational approaches, the field of miRNA biology has advanced tremendously over the last decade. Here we review the genome-wide approaches that have allowed for the discovery of new miRNAs, the characterization of their targets, and a systems-level view of their impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.