ArticleHuman genetics2011
Model-based prediction of human hair color using DNA variants.
Article in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.
- Advancement in Human Face Prediction Using DNA.Genes · 2023Pooled it
- Body pigmentation as a risk factor for the formation of intracranial aneurysms.BioMed research international · 2014Trial
- Forensic genetics in the omics era.Nature reviews. Genetics · 2026Review
- Predicting Physical Appearance from Low Template: State of the Art and Future Perspectives.Genes · 2026Review
- Forensic DNA phenotyping: a review on SNP panels, genotyping techniques, and prediction models.Forensic sciences research · 2025Review
- Changing human hair fibre colour and shape from the follicle.Journal of advanced research · 2024Article
- Predictive accuracy of genetic variants for eye color in a Kazakh population using the IrisPlex system.BMC research notes · 2024Article
- Article
- A Comprehensive Review of Mammalian Pigmentation: Paving the Way for Innovative Hair Colour-Changing Cosmetics.Biology · 2023Review
- Article
- Review
- Reliability of phenotype estimation and extended classification of ancestry using decedent samples.International journal of legal medicine · 2021Article
- Prediction of eye and hair pigmentation phenotypes using the HIrisPlex system in a Brazilian admixed population sample.International journal of legal medicine · 2021Article
- Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation.Biology open · 2021Article
- Skin pigmentation and genetic variants in an admixed Brazilian population of primarily European ancestry.International journal of legal medicine · 2020Article
- Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data.BMC genomics · 2020Article
- LitGen: Genetic Literature Recommendation Guided by Human Explanations.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2020Article
- The Use of Forensic DNA Phenotyping in Predicting Appearance and Biogeographic Ancestry.Deutsches Arzteblatt international · 2019Review
- Eye color prediction using single nucleotide polymorphisms in Saudi population.Saudi journal of biological sciences · 2019Article
- A study in scarlet: MC1R as the main predictor of red hair and exemplar of the flip-flop effect.Human molecular genetics · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Predicting complex human phenotypes from genotypes is the central concept of widely advocated personalized medicine, but so far has rarely led to high accuracies limiting practical applications. One notable exception, although less relevant for medical but important for forensic purposes, is human eye color, for which it has been recently demonstrated that highly accurate prediction is feasible from a small number of DNA variants. Here, we demonstrate that human hair color is predictable from DNA variants with similarly high accuracies. We analyzed in Polish Europeans with single-observer hair color grading 45 single nucleotide polymorphisms (SNPs) from 12 genes previously associated with human hair color variation. We found that a model based on a subset of 13 single or compound genetic markers from 11 genes predicted red hair color with over 0.9, black hair color with almost 0.9, as well as blond, and brown hair color with over 0.8 prevalence-adjusted accuracy expressed by the area under the receiver characteristic operating curves (AUC). The identified genetic predictors also differentiate reasonably well between similar hair colors, such as between red and blond-red, as well as between blond and dark-blond, highlighting the value of the identified DNA variants for accurate hair color prediction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.