ArticleJournal of biomedicine & biotechnology2011
Sperm DNA integrity and meiotic behavior assessment in an infertile male carrier of a 9qh+++ polymorphism.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- High incidences of chromosomal aberrations and Y chromosome micro-deletions as prominent causes for recurrent pregnancy losses in highly ethnic and consanguineous population.Archives of gynecology and obstetrics · 2022Article
- Parental chromosomal heteromorphisms are not associated with an increased risk of embryo aneuploidy.JBRA assisted reproduction · 2021Article
- Male chromosomal polymorphisms reduce cumulative live birth rate for IVF couples.Journal of assisted reproduction and genetics · 2017Article
- Chromosomal abnormalities in couples with repeated fetal loss: An Indian retrospective study.Indian journal of human genetics · 2013Article
- Heteromorphic variants of chromosome 9.Molecular cytogenetics · 2013Article
- Chromosome heteromorphisms: do they entail a reproductive risk for male carriers?Asian journal of andrologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although several reports on male infertility suggest a relationship between chromosome 9 polymorphisms and infertility, the effects on the phenotype have not been extensively reported. In this study, an infertile patient was found to carry a 9qh+++ chromosome. The flow cytometric TUNEL assay and SCD test have been applied to characterize sperm DNA integrity. In order to assess its meiotic behaviour, synapsis, recombination, and aneuploidy, analyses have been also performed. Sperm DNA fragmentation (SDF) was 77.81% and 87% for the TUNEL and SCD tests, respectively. Ninety-two percent of pachytene cells analyzed showed meiotic abnormalities. The mean number of MLH1 foci per pachytene in the control group was higher (49) than the mean found in the 9qh+++ patient (38) (P < .0001). In spermatozoa, significant increases of disomy rates were observed for chromosome 18 and for the sex chromosomes (P < .0001). These disturbances could be present in other male carriers of a less marked 9qh+.
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