ArticleJournal of pain research2009
Recent advances in the use of opioids for cancer pain.
Article in Journal of pain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Direct conversion from tramadol to tapentadol prolonged release for moderate to severe, chronic malignant tumour-related pain.European journal of pain (London, England) · 2016Trial
- Ready conversion of patients with well-controlled, moderate to severe, chronic malignant tumor-related pain on other opioids to tapentadol extended release.Clinical drug investigation · 2014Trial
- The pro- and anti-cancer effects of oxycodone are associated with epithelial growth factor receptor level in cancer cells.Bioscience reports · 2020Article
- Incidence of opioid-induced constipation in Japanese patients with cancer pain: A prospective observational cohort study.Cancer medicine · 2019Observational
- Tapentadol: a new option for the treatment of cancer and noncancer pains.Journal of pain research · 2019Article
- OPRM1 c.118A>G Polymorphism and Duration of Morphine Treatment Associated with Morphine Doses and Quality-of-Life in Palliative Cancer Pain Settings.International journal of molecular sciences · 2017Article
- Genotyping test with clinical factors: better management of acute postoperative pain?International journal of molecular sciences · 2015Article
- Toward a systematic approach to opioid rotation.Journal of pain research · 2014Review
- Acute abdomen in a patient with cancer pain on oxycodone.Case reports in medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opioids are the mainstay of treatment for moderate to severe cancer pain. In recent years there have been many advances in the use of opioids for cancer pain. Availability and consumption of opioids have increased and opioids other than morphine (including methadone, fentanyl, oxycodone) have become more widely used. Inter-individual variation in response to opioids has been identified as a significant challenge in the management of cancer pain. Many studies have been published demonstrating the benefits of opioid switching as a clinical maneuver to improve tolerability. Constipation has been recognized as a significant burden in cancer patients on opioids. Peripherally restricted opioid antagonists have been developed for the prevention and management of opioid induced constipation. The phenomenon of breakthrough pain has been characterized and novel modes of opioid administration (transmucosal, intranasal, sublingual) have been explored to facilitate improved management of breakthrough cancer pain. Advances have also been made in the realm of molecular biology. Pharmacogenetic studies have explored associations between clinical response to opioids and genetic variation at a DNA level. To date these studies have been small but future research may facilitate prospective prediction of response to individual drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.