Evidence map›Paper›PMID 21197216›Full record

ReviewOrganogenesis

Strategies for organ level tissue engineering.

Kristine C Rustad, Michael Sorkin, Benjamin Levi, Michael T Longaker, Geoffrey C Gurtner

Abstract readReview
In one paragraph

Review in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Stem cells and common biomaterials in dentistry: a review study.Journal of materials science. Materials in medicine · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Synthetic Biology in Cell and Organ Transplantation.Cold Spring Harbor perspectives in biology · 2017
    Review
  14. 3D Bioprinting for Organ Regeneration.Advanced healthcare materials · 2017
    Review
  15. Article
  16. Article
  17. Article
  18. Why we cannot grow a human arm.Journal of materials science. Materials in medicine · 2013
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristine C RustadStanford University, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford, CA, USA.
Michael Sorkin
Benjamin Levi
Michael T Longaker
Geoffrey C Gurtner

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The field of tissue engineering has made considerable strides since it was first described in the late 1980s. The advent and subsequent boom in stem cell biology, emergence of novel technologies for biomaterial development and further understanding of developmental biology have contributed to this accelerated progress. However, continued efforts to translate tissue-engineering strategies into clinical therapies have been hampered by the problems associated with scaling up laboratory methods to produce large, complex tissues. The significant challenges faced by tissue engineers include the production of an intact vasculature within a tissue-engineered construct and recapitulation of the size and complexity of a whole organ. Here we review the basic components necessary for bioengineering organs-biomaterials, cells and bioactive molecules-and discuss various approaches for augmenting these principles to achieve organ level tissue engineering. Ultimately, the successful translation of tissue-engineered constructs into everyday clinical practice will depend upon the ability of the tissue engineer to "scale up" every aspect of the research and development process.

Indexed as

Organ Culture TechniquesTissue EngineeringTissue ScaffoldsAnimalsHumansadipose-derived stromal cellsbiomaterialsgrowth factorsregenerative medicinescale upstem cellstissue engineering

Identifiers

PMID21197216
PMCPMC2946046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.