ArticlePaediatrics & child health2010
Is lead a concern in Canadian autistic children?
Article in Paediatrics & child health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Systematic Review: Overlap Between Eating, Autism Spectrum, and Attention-Deficit/Hyperactivity Disorder.Frontiers in psychiatry · 2019Pooled it
- Environmental toxicants and autism spectrum disorders: a systematic review.Translational psychiatry · 2014Pooled it
- Perinatal Exposure to Trace Elements: The Dubious Culprit of Autistic Spectrum Disorder in Children.Current pediatric reviews · 2024Review
- Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals.International journal of molecular sciences · 2022Review
- Prevalence of pica and rumination behaviours in adults and associations with eating disorder and general psychopathology: findings form a population-based study.Epidemiology and psychiatric sciences · 2022Article
- Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in the Blood of Pakistani Children with and without Autism Spectrum Disorder and Their Associated Factors.International journal of environmental research and public health · 2021Article
- The Metallome as a Link Between the "Omes" in Autism Spectrum Disorders.Frontiers in molecular neuroscience · 2021Review
- Interaction between a Mixture of Heavy Metals (Lead, Mercury, Arsenic, Cadmium, Manganese, Aluminum) andResearch in autism spectrum disorders · 2020Article
- Concentrations of Lead, Mercury, Arsenic, Cadmium, Manganese, and Aluminum in Blood of Romanian Children Suspected of Having Autism Spectrum Disorder.International journal of environmental research and public health · 2019Article
- Children With Autism Spectrum Disorder and Lead Poisoning: Diagnostic Challenges and Management Complexities.Clinical pediatrics · 2019Review
- Interaction between manganese andResearch in autism spectrum disorders · 2018Article
- Blood lead concentrations in Jamaican children with and without autism spectrum disorder.International journal of environmental research and public health · 2014Article
- Blood lead concentrations and children's behavioral and emotional problems: a cohort study.JAMA pediatrics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Centers for Disease Control and Prevention (CDC) threshold for intervention for blood lead level (BLL) is greater than 0.48 μmol/L, but new research suggests that there are adverse effects at any level of exposure. Children with autism are at increased risk for lead exposure and intoxication, and have later and more prolonged exposures because of exploratory oral behaviours and pica.
objectiveTo estimate the mean BLL and prevalence of high BLL in a convenience sample of autistic children living in northern Alberta, based on the CDC threshold for intervention.
methodsChildren with autism were recruited from the clinics at the Glenrose Rehabilitation Hospital in Edmonton, Alberta. A complete blood count and differential, serum ferritin and BLL were requested after consent was obtained. Summary statistics were reported. For dichotomous outcomes, proportions were presented. Continuous outcomes for the two groups with a BLL of 0.1 μmol/L or greater, or less than 0.1 μmol/L were compared.
resultsNone of the children tested had a BLL exceeding 0.48 μmol/L. Nine children (19%) had BLLs of 0.1 μmol/L or greater but less than 0.48 μmol/L, and 39 (81%) had BLLs of less than 0.1 μmol/L. Those with a BLL of 0.1 μmol/L or greater had significantly more pica or oral exploratory behaviours.
conclusionChildren with autism in northern Alberta may not be at risk for elevated BLLs that exceed the CDC threshold for intervention. They should be screened for lead exposure risk factors and tested if there are risks, especially behaviours relating to pica and oral exploration of objects. Clinicians may need to further explore the reasons for low-level exposures to lead in the autistic population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.