ArticleDepression research and treatment2011
Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder.
Article in Depression research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00851006 (Adjunctive Creatine Treatment for Adolescent Females With Major Depressive Disorder Who Are Non-Responders to Fluoxetine or Escitalopram), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adjunctive Creatine Treatment for Adolescent Females With Major Depressive Disorder Who Are Non-Responders to Fluoxetine or Escitalopram: A Magnetic Resonance Spectroscopy Study
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics.Progress in neuro-psychopharmacology & biological psychiatry · 2015Pooled it
- The Utility of Magnetic Resonance Spectroscopy for Understanding Substance Use Disorders: A Systematic Review of the Literature.Journal of the American Psychiatric Nurses AssociationPooled it
- Ultra-high field magnetic resonance spectroscopy study of transcranial magnetic stimulation treatment in adolescents with depression.BMC psychiatry · 2026Trial
- Trial
- Trial
- Real-Time Neurofeedback Training to Modulate Glutamate-Glutamine Concentration Using Functional Magnetic Resonance Spectroscopy.NMR in biomedicine · 2026Article
- ATP bioenergetics and fatigue in young adults with and without major depression.Translational psychiatry · 2026Article
- Connecting Dots between Mitochondrial Dysfunction and Depression.Biomolecules · 2023Review
- Ferroptosis: a new antidepressant pharmacological mechanism.Frontiers in pharmacology · 2023Review
- A review of applications of surface-enhanced raman spectroscopy laser for detection of biomaterials and a quick glance into its advances for COVID-19 investigations.ISSS journal of micro and smart systems · 2022Article
- The rat cumulative allostatic load measure (rCALM): a new translational assessment of the burden of stress.Environmental epigenetics · 2019Article
- Ultra-High-Field Magnetic Resonance Spectroscopy in Psychiatry.Frontiers in psychiatry · 2017Review
- Increased ventricular cerebrospinal fluid lactate in depressed adolescents.European psychiatry : the journal of the Association of European Psychiatrists · 2016Article
- Transcranial magnetic stimulation potentiates glutamatergic neurotransmission in depressed adolescents.Psychiatry research. Neuroimaging · 2016Article
- An Exploratory Study of Spectroscopic Glutamatergic Correlates of Cortical Excitability in Depressed Adolescents.Frontiers in neural circuits · 2016Article
- Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a (1)H magnetic resonance spectroscopy study.BMC psychiatry · 2015Article
- Proton magnetic resonance spectroscopy (MRS) in on-line game addiction.Journal of psychiatric research · 2014Article
- A review of MR spectroscopy studies of pediatric bipolar disorder.AJNR. American journal of neuroradiology · 2014Review
- Imaging the pathophysiology of major depressive disorder - from localist models to circuit-based analysis.Biology of mood & anxiety disorders · 2014Article
- Anterior cingulate cortex choline levels in female adolescents with unipolar versus bipolar depression: a potential new tool for diagnosis.Journal of affective disorders · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Introduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health's PubMed database was conducted to identify indexed peer-reviewed MRS studies in pediatric patients with MDD. Results. The literature search yielded 18 articles reporting original MRS data in pediatric MDD. Neurochemical alterations in Choline, Glutamate, and N-Acetyl Aspartate are associated with pediatric MDD, suggesting pathophysiologic continuity with adult MDD. Conclusions. The MRS literature in pediatric MDD is modest but growing. In studies that are methodologically comparable, the results have been consistent. Because it offers a noninvasive and repeatable measurement of relevant in vivo brain chemistry, MRS has the potential to provide insights into the pathophysiology of MDD as well as the mediators and moderators of treatment response.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.