ArticleNature2011
Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 99 citations in OpenAlex.
- Spatial transcriptomics ofiScience · 2026Article
- Similarities betweeneNeuro · 2026Article
- Embodied postural dynamics underlie behavioral diversity in a benthic sessile chordate.iScience · 2026Article
- Proteome analysis refines molecular processes underlying metamorphosis in the ascidian Ciona intestinalis.PloS one · 2026Article
- Tunicates have a complex, highly dynamic TNF superfamily.PloS one · 2026Article
- The dorsal/ventral subdivision of the hindbrain predates the tunicate/vertebrate split.bioRxiv : the preprint server for biology · 2025Article
- A simple inland culture system provides insights into ascidian post-embryonic developmental physiology.Open biology · 2025Article
- Article
- Specification and survival of post-metamorphic branchiomeric neurons in a non-vertebrate chordate.Development (Cambridge, England) · 2024Article
- Deep homologies in chordate caudal central nervous systems.bioRxiv : the preprint server for biology · 2024Article
- Development and circuitry of the tunicate larval Motor Ganglion, a putative hindbrain/spinal cord homolog.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- A single oscillating proto-hypothalamic neuron gates taxis behavior in the primitive chordate Ciona.Current biology : CB · 2023Article
- Specification and survival of post-metamorphic branchiomeric neurons in the hindbrain of a non-vertebrate chordate.bioRxiv : the preprint server for biology · 2023Article
- A single oscillating proto-hypothalamic neuron gates taxis behavior in the primitive chordatebioRxiv : the preprint server for biology · 2023Article
- Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System.Aging and disease · 2023Review
- Exploring tissue morphodynamics using the photoconvertible Kaede protein in amphioxus embryos.PloS one · 2022Article
- A single motor neuron determines the rhythm of early motor behavior inScience advances · 2021Article
- Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data.Nature communications · 2021Article
- Neuromesodermal Lineage Contribution to CNS Development in Invertebrate and Vertebrate Chordates.Genes · 2021Review
- A cis-regulatory change underlying the motor neuron-specific loss of Ebf expression in immotile tunicate larvae.Evolution & development · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In ascidian tunicates, the metamorphic transition from larva to adult is accompanied by dynamic changes in the body plan. For instance, the central nervous system (CNS) is subjected to extensive rearrangement because its regulating larval organs are lost and new adult organs are created. To understand how the adult CNS is reconstructed, we traced the fate of larval CNS cells during ascidian metamorphosis by using transgenic animals and imaging technologies with photoconvertible fluorescent proteins. Here we show that most parts of the ascidian larval CNS, except for the tail nerve cord, are maintained during metamorphosis and recruited to form the adult CNS. We also show that most of the larval neurons disappear and only a subset of cholinergic motor neurons and glutamatergic neurons are retained. Finally, we demonstrate that ependymal cells of the larval CNS contribute to the construction of the adult CNS and that some differentiate into neurons in the adult CNS. An unexpected role of ependymal cells highlighted by this study is that they serve as neural stem-like cells to reconstruct the adult nervous network during chordate metamorphosis. Consequently, the plasticity of non-neuronal ependymal cells and neuronal cells in chordates should be re-examined by future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.