ArticleAmerican journal of nephrology2011
Podocyte number in the maturing rat kidney.
Article in American journal of nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Glomage: A Multimodal Platform for High-Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Effects of Prothrombin on Podocytopathy and Proteinuria in Glomerular Disease.Journal of the American Society of Nephrology : JASN · 2025Article
- Nephrons, podocytes and chronic kidney disease: Strategic antihypertensive therapy for renoprotection.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- AMPK mediates regulation of glomerular volume and podocyte survival.JCI insight · 2021Article
- Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Podocyte Foot Process Effacement Precedes Albuminuria and Glomerular Hypertrophy in CD2-Associated Protein Deficient Mice.Frontiers in medicine · 2021Article
- SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts.Journal of the American Society of Nephrology : JASN · 2018Article
- Article
- Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure.Journal of the American Society of Nephrology : JASN · 2016Article
- The phenotypes of podocytes and parietal epithelial cells may overlap in diabetic nephropathy.Kidney international · 2015Article
- Dendrin ablation prolongs life span by delaying kidney failure.The American journal of pathology · 2015Article
- Glycogen synthase kinase 3β orchestrates microtubule remodeling in compensatory glomerular adaptation to podocyte depletion.The Journal of biological chemistry · 2015Article
- Estimating podocyte number and density using a single histologic section.Journal of the American Society of Nephrology : JASN · 2014Article
- Early chronic low-level lead exposure produces glomerular hypertrophy in young C57BL/6J mice.Toxicology letters · 2014Article
- Reversibility of structural and functional damage in a model of advanced diabetic nephropathy.Journal of the American Society of Nephrology : JASN · 2013Article
- Using stereologic techniques for podocyte counting in the mouse: shifting the paradigm.American journal of nephrology · 2011Article
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Authors and funding
2 authors.
Funding
Abstract
BACKGROUND/
aimsThe podocyte is an important cell for maintaining the normal structure and function of the glomerulus. In recent years much attention has been given to the number of podocytes in glomeruli. During this time there has been a debate as to whether podocytes can divide after the capillary-loop stage of development. The aim of this study was to use an unbiased counting method to determine if podocyte number increases after the capillary-loop stage of development.
methodsThe fractionator/disector method was used to count podocytes in glomeruli from rats aged 1 day, 5, 12, and 24 weeks. Glomerular volume was also measured with the unbiased Cavalieri principle and used to calculate the density of podocytes per glomerulus.
resultsThe number of podocytes did not increase from the capillary-loop stage of glomerular development to 24 weeks of age. Glomerular volume increased 3.6-fold during this time, which resulted in a decrease of podocyte density as the rats aged.
conclusionThe study documents that the number of podocytes is stable after the capillary-loop stage of glomerular development. The data does not confirm but adds evidence that podocytes do not divide from the capillary-loop stage of glomerular development to 24 weeks of age in the normal rat.
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