ArticleGenetics2011
Detecting directional selection in the presence of recent admixture in African-Americans.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Popformer: Learning general signatures of positive selection with a self-supervised transformer.PLoS computational biology · 2026Article
- Article
- Popformer: Learning general signatures of positive selection with a self-supervised transformer.bioRxiv : the preprint server for biology · 2026Article
- Localizing Post-Admixture Adaptive Variants with Object Detection on Ancestry-Painted Chromosomes.Molecular biology and evolution · 2023Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- The genomic signatures of natural selection in admixed human populations.American journal of human genetics · 2022Article
- Changes in selection pressure can facilitate hybridization during biological invasion in a Cuban lizard.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Inferring Adaptive Introgression Using Hidden Markov Models.Molecular biology and evolution · 2021Article
- Human genetic admixture.PLoS genetics · 2021Review
- Rapid adaptation to malaria facilitated by admixture in the human population of Cabo Verde.eLife · 2021Article
- Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas.Frontiers in genetics · 2021Article
- Positive selection in admixed populations from Ethiopia.BMC genetics · 2020Article
- Complex patterns of sex-biased demography in canines.Proceedings. Biological sciences · 2019Article
- Inference on admixture fractions in a mechanistic model of recurrent admixture.Theoretical population biology · 2018Article
- Patterns of Genetic Coding Variation in a Native American Population before and after European Contact.American journal of human genetics · 2018Article
- Detecting recent selective sweeps while controlling for mutation rate and background selection.Molecular ecology · 2016Article
- Article
- Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes.Genome biology and evolution · 2015Article
- Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity.BMC genomics · 2015Article
Corrections and comments
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3 authors.
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Abstract
We investigate the performance of tests of neutrality in admixed populations using plausible demographic models for African-American history as well as resequencing data from African and African-American populations. The analysis of both simulated and human resequencing data suggests that recent admixture does not result in an excess of false-positive results for neutrality tests based on the frequency spectrum after accounting for the population growth in the parental African population. Furthermore, when simulating positive selection, Tajima's D, Fu and Li's D, and haplotype homozygosity have lower power to detect population-specific selection using individuals sampled from the admixed population than from the nonadmixed population. Fay and Wu's H test, however, has more power to detect selection using individuals from the admixed population than from the nonadmixed population, especially when the selective sweep ended long ago. Our results have implications for interpreting recent genome-wide scans for positive selection in human populations.
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