ReviewFrontiers in bioscience (Scholar edition)2011
Sleep and innate immunity.
Review in Frontiers in bioscience (Scholar edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 5 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Sleep Deprivation, Cytokine Dysregulation, and the Risk of Cardiac Arrhythmia in Dogs.Veterinary medicine and science · 2026Pooled it
- The association between sleep quantity, insomnia and lung cancer risk - A systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- A Systematic Review of Publications on the Associations Between Sleep Architecture and Arterial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2023Pooled it
- Effect of sleep loss on pain-New conceptual and mechanistic avenues.Frontiers in neuroscience · 2022Pooled it
- Risk factors for sleep disturbances in older adults: Evidence from prospective studies.Sleep medicine reviews · 2016Pooled it
- Trial
- Preexisting mild sleep disturbance as a vulnerability factor for inflammation-induced depressed mood: a human experimental study.Translational psychiatry · 2016Trial
- Association of Periodontal Disease with Sleep Quality and Oral Health-Related Quality of Life: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- A dermo-hypothalamic axis driven by TNF-α mediates sleep disturbances in psoriasis.Communications biology · 2026Article
- Sleep and Cytokines: A Bidirectional Dialogue Involving Rest and Immunity.Children (Basel, Switzerland) · 2026Review
- Acute sleep deprivation alters hypothalamic neuroinflammatory signaling independent of traumatic brain injury in the mouse.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Brainstem circuit for sickness-induced sleep.Science advances · 2025Article
- IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications.Brain, behavior, & immunity - health · 2025Review
- A [Journal of neuroinflammation · 2025Article
- Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection.Neurobiology of sleep and circadian rhythms · 2025Article
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- Sleep and immune health: How dogs, goats and 'factor S' shaped a field.Neurobiology of sleep and circadian rhythms · 2025Article
- Psychophysical changes after total sleep deprivation and experimental muscle pain.Journal of sleep research · 2025Article
- Altered brain-derived neurotrophic factor levels and oxidative stress in REM sleep deprivation: a rat model study.BMC neurology · 2025Article
- Association between Sleep Quality and Periodontal Status: A Case-Control Study.Journal of dentistry (Shiraz, Iran) · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many pro-inflammatory molecules, such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are somnogenic, while many anti-inflammatory molecules inhibit sleep. Sleep loss increases the production/release of these sleep regulatory pro-inflammatory molecules. Further, sleep changes occurring during various pathologies are mediated by these inflammatory substances in response to pathogen recognition and subsequent inflammatory cellular pathways. This review summarizes information and concepts regarding inflammatory mechanisms of the innate immune system that mediate sleep. Further, we discuss sleep-immune interactions in regards to sleep in general, pathologies, and sleep as a local phenomenon including the central role that extracellular ATP plays in the initiation of sleep.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.