ReviewFrontiers in bioscience (Scholar edition)2011
Adipose tissue as a stem cell source for musculoskeletal regeneration.
Review in Frontiers in bioscience (Scholar edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair.Biomedicines · 2022Review
- The equine navicular apparatus as a premier enthesis organ: Functional implications.Veterinary surgery : VS · 2021Review
- Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10.Stem cell research & therapy · 2021Article
- The role of adipose derived stem cells in the treatment of rotator cuff tears: from basic science to clinical application.Orthopedic reviews · 2020Article
- Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Immunomodulatory Effects of MSCs in Bone Healing.International journal of molecular sciences · 2019Review
- Adipose-derived Stem/Stromal Cells on Electrospun Fibrin Microfiber Bundles Enable Moderate Muscle Reconstruction in a Volumetric Muscle Loss Model.Cell transplantation · 2018Article
- Wet milling of large quantities of human excision adipose tissue for the isolation of stromal vascular fraction cells.Cytotechnology · 2018Article
- Platelet-Derived Growth Factor Receptor-Positive Pericytic Cells of White Adipose Tissue from Critical Limb Ischemia Patients Display Mesenchymal Stem Cell-Like Properties.Clinics in orthopedic surgery · 2017Article
- Effect of Uniaxial Tensile Cyclic Loading Regimes on Matrix Organization and Tenogenic Differentiation of Adipose-Derived Stem Cells Encapsulated within 3D Collagen Scaffolds.Stem cells international · 2017Article
- Adipose-Derived Stem Cells as a Tool in Cell-Based Therapies.Archivum immunologiae et therapiae experimentalis · 2016Review
- Adipose-derived human stem/stromal cells: comparative organ specific mitochondrial bioenergy profiles.SpringerPlus · 2016Article
- Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome.Endocrinology · 2015Article
- Stem cell therapy in the management of shoulder rotator cuff disorders.World journal of stem cells · 2015Review
- Molecular physiognomies and applications of adipose-derived stem cells.Stem cell reviews and reports · 2015Review
- Stem cell technology for bone regeneration: current status and potential applications.Stem cells and cloning : advances and applications · 2015Review
- Live-cell, temporal gene expression analysis of osteogenic differentiation in adipose-derived stem cells.Tissue engineering. Part A · 2014Article
- A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue.World journal of stem cells · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Adipose tissue is an abundant, easily accessible, and reproducible cell source for musculo-skeletal regenerative medicine applications. Initial derivation steps yield a heterogeneous population of cells of stromal vascular fraction (SVF) cells. Subsequent adherent selection of the SVF results in a relatively homogeneous population of adipose-derived stromal/stem cells (ASCs) capable of adipogenic, chondrogenic, myogenic, and osteogenic differentiation in vitro on scaffolds in bioreactors and in vivo in pre-clinical animal models. Unlike hematopoietic cells, ASCs do not elicit a robust lymphocyte reaction and instead release immunosuppressive factors, such as prostaglandin E2. These immunomodulatory features suggest that allogeneic and autologous ASCs will engraft successfully for tissue regeneration purposes. The differentiation and expansion potential of ASCs can be modified by growth factors, bio-inductive scaffolds, and bioreactors providing environmental control and biophysical stimulation. Gene therapy approaches using lentiviral transduction can be used to direct differentiation of ASCs to particular lineages. We discuss the utility of ASCs for musculo-skeletal tissue repair and some of the technologies that can be implemented to unlock the full regenerative potential of these highly valuable cells.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.