ReviewFrontiers in bioscience (Elite edition)2011
Dentin: structure, composition and mineralization.
Review in Frontiers in bioscience (Elite edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 290 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
290 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Age estimation using the pulp-to-tooth volume ratio of canines based on cone-beam computed tomography: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Effect of diabetes and hyperglycaemia on the physical and mechanical properties of dentine: a systematic review.Clinical oral investigations · 2025Pooled it
- Dental Abnormalities in Osteogenesis Imperfecta: A Systematic Review.Calcified tissue international · 2024Pooled it
- Clinical, radiographic, and histological evaluation of autogenous demineralized dentin matrix versus xenograft in alveolar ridge preservation: a randomized controlled trial.International journal of implant dentistry · 2026Trial
- Dentine-derived barrier membrane versus extended platelet-rich fibrin for guided bone regeneration: a 2-year randomized clinical trial.BMC oral health · 2026Trial
- Beyond the diagnosis: UnravelingThe Japanese dental science review · 2026Review
- Geometry-Dependent Osteogenic Performance of Demineralized Dentin Matrix as a Carrier for rhBMP-2.Tissue engineering and regenerative medicine · 2026Article
- Effect of dentin conditioners on biomarker release and microhardness of radicular dentin: an in vitro study.BMC oral health · 2026Article
- Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses.bioRxiv : the preprint server for biology · 2026Article
- Enhanced odontoblast regeneration and anti-inflammatory effects of nanocurcumin-loaded BM-MSC-derived exosomes in an LPS-induced periodontitis rat model.BMC oral health · 2026Article
- An Autologous Tooth-Shell Technique for Ridge Reconstruction and Immediate Implant Placement: A Two-Case Technical Report and Review of the Literature.Journal of functional biomaterials · 2026Article
- Ultrastructural Evaluation of Newly Formed Dentine After Direct Pulp Capping With Mineral Trioxide Aggregate and Calcium Hydroxide Using Focused Ion Beam Scanning Electron Microscopy and Stimulated Emission Depletion.International endodontic journal · 2026Article
- Dual-Functional Gel-Based Delivery of Chitosan-Coated Gold Nanoparticles for Accelerated Bone Healing in Defect Models.Pharmaceutics · 2026Article
- Dissolution versus dislodgment of dentin debris by pulsed erbium-doped yttrium aluminum garnet laser-activated endodontic irrigants.Lasers in medical science · 2026Article
- Biomimetic strategies for the dentin mineralization, using bioactive molecules: a scoping review and bibliometric analysis (2015-2025).Odontology · 2026Review
- Non-decalcified human teeth sample preparation method for MALDI mass spectrometry imaging.Analytica chimica acta · 2026Article
- Effects and Properties of Deproteinizing Methods in Dentin: A Comprehensive Narrative Review.Journal of functional biomaterials · 2026Review
- Effects of Collagen Cross-Linking Agents on Dentin-Composite Interface Strength and Morphology.Calcified tissue international · 2026Article
- Spondin-1 Inhibits Odontoblastic Differentiation of Human Dental Pulp Stem Cells.Biomolecules · 2026Article
- DPP-Mediated Interaction of TAZ/β-Catenin Promotes the Differentiation of DPSCs into Odontoblasts.International journal of molecular sciences · 2026Article
230 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We review firstly the specificities of the different types of dentin present in mammalian teeth. The outer layers include the mantle dentin, the Tomes' granular and the hyaline Hopewell-Smith's layers. Circumpulpal dentin forming the bulk of the tooth, comprises intertubular and peritubular dentin. In addition to physiological primary and secondary dentin formation, reactionary dentin is produced in response to pathological events. Secondly, we evaluate the role of odontoblasts in dentin formation, their implication in the synthesis and secretion of type I collagen fibrils and non-collagenous molecules. Thirdly, we study the composition and functions of dentin extracellular matrix (ECM) molecules implicated in dentinogenesis. As structural proteins they are mineralization promoters or inhibitors. They are also signaling molecules. Three different forms of dentinogenesis are identified: i) matrix vesicles are implicated in early dentin formation, ii) collagen and some proteoglycans are involved in the formation of predentin, further transformed into intertubular dentin, iii) the distal secretion of some non-collagenous ECM molecules and some serum proteins contribute to the formation of peritubular dentin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.