ReviewFrontiers in bioscience (Landmark edition)2011
Colon cancer stem cells: implications in carcinogenesis.
Review in Frontiers in bioscience (Landmark edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed.
- Colorectal adenoma stem-like cell populations: associations with adenoma characteristics and metachronous colorectal neoplasia.Cancer prevention research (Philadelphia, Pa.) · 2013Trial
- Impact of propofol on gastrointestinal cancer outcomes: A review of cellular behavior, growth, and metastasis.World journal of clinical oncology · 2025Review
- Crosstalk between GLTSCR1-deficient endothelial cells and tumour cells promotes colorectal cancer development by activating the Notch pathway.Cell death and differentiation · 2025Article
- Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights.Current pharmaceutical design · 2024Review
- Propofol inhibits colon cancer cell stemness and epithelial-mesenchymal transition by regulating SIRT1, Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways.Discover oncology · 2023Article
- Evaluation of LGR5 Cancer Stem Cell Marker Expression in Breast Cancer and Its Relationship with Hormonal Profile and Clinical Pathological Features.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment.Cell death & disease · 2021Article
- Article
- Diet-Derived Phytochemicals Targeting Colon Cancer Stem Cells and Microbiota in Colorectal Cancer.International journal of molecular sciences · 2020Review
- Potential theranostics of circulating tumor cells and tumor-derived exosomes application in colorectal cancer.Cancer cell international · 2020Review
- HotspotOncotarget · 2018Article
- Colon cancer recurrence‑associated genes revealed by WGCNA co‑expression network analysis.Molecular medicine reports · 2017Article
- The role of GLI1 for 5-Fu resistance in colorectal cancer.Cell & bioscience · 2017Article
- Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas.Stem cell reports · 2016Article
- Racial disparity in colorectal cancer: Gut microbiome and cancer stem cells.World journal of stem cells · 2016Review
- Isolation of colorectal cancer stem-like cells.Cytotechnology · 2016Article
- Comparison of leucine-rich repeat-containing G protein-coupled receptor 5 expression in different cancer and normal cell lines.Biomedical reports · 2016Article
- Article
- Role of cancer stem cells in age-related rise in colorectal cancer.World journal of gastrointestinal pathophysiology · 2015Article
- Detection and Clinical Significance of Circulating Tumor Cells in Colorectal Cancer--20 Years of Progress.Molecular medicine (Cambridge, Mass.) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The cancer stem cell model was described for hematologic malignancies in 1997 and since then evidence has emerged to support it for many solid tumors as well, including colon cancer. This model proposes that certain cells within the tumor mass are pluripotent and capable of self-renewal and have an enhanced ability to initiate distant metastasis. The cancer stem cell model has important implications for cancer treatment, since most current therapies target actively proliferating cells and may not be effective against the cancer stem cells that are responsible for recurrence. In recent years great progress has been made in identifying markers of both normal and malignant colon stem cells. Proteins proposed as colon cancer stem cell markers include CD133, CD44, CD166, ALDH1A1, Lgr5, and several others. In this review we consider the evidence for these proteins as colon cancer stem cell markers and as prognostic indicators of colon cancer survival. Additionally, we discuss potential functions of these proteins and the implications this may have for development of therapies that target colon cancer stem cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.