ReviewFrontiers in bioscience (Landmark edition)2011
Receptor-mediated T cell absorption of antigen presenting cell-derived molecules.
Review in Frontiers in bioscience (Landmark edition), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- T cell decision-making decodes the dynamic antigenic landscape.Frontiers in immunology · 2026Review
- Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker.Gut pathogens · 2020Review
- Isolation and Analysis of Tumor-Derived Exosomes.Current protocols in immunology · 2019Article
- Peripheral Blood Cell Interactions of Cancer-Derived Exosomes Affect Immune Function.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2019Article
- Uptake of lymphoma-derived exosomes by peripheral blood leukocytes.Blood and lymphatic cancer : targets and therapy · 2017Article
- Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer.Journal of extracellular vesicles · 2016Article
- Lipid raft-dependent plasma membrane repair interferes with the activation of B lymphocytes.The Journal of cell biology · 2015Article
- Addition of CpG ODN and Poly (I:C) to a standard maturation cocktail generates monocyte-derived dendritic cells and induces a potent Th1 polarization with migratory capacity.Human vaccines & immunotherapeutics · 2015Article
- A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods.Journal of translational medicine · 2014Review
- Cell-cell communication via extracellular membrane vesicles and its role in the immune response.Molecules and cells · 2013Review
- Quantifying T lymphocyte turnover.Journal of theoretical biology · 2013Article
- Antigen-stimulated CD4 T cell expansion can be limited by their grazing of peptide-MHC complexes.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Parapharyngeal liposarcoma: a case report.Diagnostic pathology · 2013Article
- Exosomal tumor microRNA modulates premetastatic organ cells.Neoplasia (New York, N.Y.) · 2013Article
- Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
T cells tend to acquire a variety of cell surface molecules derived from antigen presenting cells (APCs). The molecule uptake occurs mainly during direct T/APC contact and is instigated by specific receptor/ligand interactions, such as T cell receptor (TCR) with a cognate peptide/MHC complex (pMHC) or CD28 with B7. The acquired molecules are targeted for internalization and degradation in the lysosome. Nevertheless, those molecules are expressed on the surface of T cells for a period of time. The presentation of APC-derived ligands by T cells exhibited a multitude of immunological effects via antigen-specific T/T interaction upon recognition of the absorbed antigens by contact with other T cells. Ligand uptake also occurs via absorption of membrane vesicles shed from APCs prior to contact (e.g., exosomes and plasma membrane-derived vesicles). As in ligand absorption via direct T/APC interaction, the absorption of pre-formed membrane vesicles is also dependent on specific receptor/ligand interactions. In this review, biological mechanisms underlying the ligand absorption process as well as the biological significance and application of the event will be discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.