ArticleResearch in veterinary science2012
Antiviral activity of Alpinia katsumadai extracts against rotaviruses.
Article in Research in veterinary science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- In Vitro Anti-Rotaviral Activity of Bavachin Isolated fromVeterinary sciences · 2024Article
- Article
- Advances in the development of antivirals for rotavirus infection.Frontiers in immunology · 2023Review
- In Vitro Evaluation of Anti-Rotaviral Activity and Intestinal Toxicity of a Phytotherapeutic Prototype ofViruses · 2022Article
- Anti-Periodontitis Effect of Ethanol Extracts ofNutrients · 2021Article
- Medicinal plants: Treasure for antiviral drug discovery.Phytotherapy research : PTR · 2021Review
- Genipin inhibits rotavirus-induced diarrhea by suppressing viral replication and regulating inflammatory responses.Scientific reports · 2020Article
- Acyclic Triterpenoids from Alpinia katsumadai Inhibit IL-6-Induced STAT3 Activation.Molecules (Basel, Switzerland) · 2017Article
- In vitro Antiviral Activity of Rubia cordifolia Aerial Part Extract against Rotavirus.Frontiers in pharmacology · 2016Article
- In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae).BMC complementary and alternative medicine · 2015Article
- In vitro antiviral activity of phlorotannins isolated from Ecklonia cava against porcine epidemic diarrhea coronavirus infection and hemagglutination.Bioorganic & medicinal chemistry · 2013Article
- In Vitro Anti-rotaviral Activity of Achillea kellalensis.Jundishapur journal of natural pharmaceutical products · 2013Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro anti-rotavirus activity of Alpinia katsumadai (AK) extracts were evaluated against bovine G8P[7] and porcine G5P[7] rotaviruses in two different assay strategies, a mixed treatment assay and a post treatment assay. In the mixed treatment assay, six AK extracts [AK-1 (EtOH extract), AK-3 (H(2)O layer), AK-5 (40% methanol fraction), and AK-9-11 (H(2)O extract, polysaccharide fraction, supernatant fraction)] exhibited inhibitory activities against G5P[7] rotavirus with the EC(50) values ranging from 0.7±0.4 to 33.7±6.5 μg/mL. Extracts AK-1, AK-3, and AK-5 inhibited rotavirus infection against G8P[7] rotavirus, the with EC(50) values of 8.4±2.2 μg/mL, 6.5±0.8 μg/mL and 8.4±5.0 μg/mL, respectively. By hemagglutination inhibition (HI) assay, six AK extracts completely inhibited viral adsorption onto human RBCs in both strains of rotaviruses at less than 11 μg/mL. However, in the post treatment assay, there was no anti activity shown against both strains of rotaviruses. As a result, six AK extracts were attributed mainly to having a strong interaction with hemagglutinin protein on the outer surface of rotavirus, resulting to blockage of viral adsorption.
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