ArticleNeuroscience2011
Genetic disruption of Met signaling impairs GABAergic striatal development and cognition.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- The promise of gene therapy in common types of dementia.BioImpacts : BI · 2025Review
- Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis.Metabolic brain disease · 2024Article
- The role of neuroactive steroids in tic disorders.Neuroscience and biobehavioral reviews · 2024Review
- Cyclic Peptide-Based Biologics Regulating HGF-MET.International journal of molecular sciences · 2020Review
- The attention set-shifting test is sensitive for revealing sex-based impairments in executive functions following developmental lead exposure in rats.Behavioural brain research · 2019Article
- Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Estrogen Treatment Reverses Prematurity-Induced Disruption in Cortical Interneuron Population.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Cortical interneuron development: a tale of time and space.Development (Cambridge, England) · 2017Review
- The Pleiotropic MET Receptor Network: Circuit Development and the Neural-Medical Interface of Autism.Biological psychiatry · 2017Review
- Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder.Translational psychiatry · 2016Article
- Insulin-Independent GABAA Receptor-Mediated Response in the Barrel Cortex of Mice with Impaired Met Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Striatal Circuits as a Common Node for Autism Pathophysiology.Frontiers in neuroscience · 2016Review
- Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities.Translational psychiatry · 2015Article
- Interneurons are necessary for coordinated activity during reversal learning in orbitofrontal cortex.Biological psychiatry · 2015Article
- A MicroRNA Profile in Fmr1 Knockout Mice Reveals MicroRNA Expression Alterations with Possible Roles in Fragile X Syndrome.Molecular neurobiology · 2015Article
- HGF-Met Pathway in Regeneration and Drug Discovery.Biomedicines · 2014Review
- Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders.Molecular psychiatry · 2014Review
- Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons.Behavioural brain research · 2014Article
- Neural structures underlying set-shifting: roles of medial prefrontal cortex and anterior cingulate cortex.Behavioural brain research · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The largest structure of the basal ganglia, the striatum, modulates motor activity and cognitive function and is composed of GABAergic projection neurons and interneurons. To better understand the mechanisms underlying the development of the striatal neurons and their assembly into functional circuits, we used a mouse with a targeted conditional Met mutation in post-mitotic cells of the ventral telencephalon. Characterization of the ontogeny of the striatal neuronal populations demonstrated that disruption of Met signaling specifically altered the GABAergic interneurons. Medium spiny neurons (MSNs) and cholinergic interneurons were largely unaffected. Mice lacking Met signaling have increased numbers of striatal GABAergic interneurons in the lateral sensorimotor areas with distinct behavioral deficits. Motor function and memory formation and consolidation appeared intact, but procedural learning on the cued task of the Morris water maze was delayed. MET is a susceptibility gene in Tourette syndrome and autism, which are human disorders with impaired procedural learning. This study reveals how a striatal targeted disruption in Met signaling after generation of striatal neurons produces behavioral phenotypes shared by Tourette syndrome and autism, linking the human genetics with the mechanism underlying the disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.