ArticleCell metabolism2011
Decoupling ferritin synthesis from free cytosolic iron results in ferritin secretion.
Article in Cell metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Effects of maternal anemia on low-birth-weight in Sub-Sahara African countries: Systematic review and meta-analysis.PloS one · 2025Pooled it
- Elevation in multiple serum inflammatory biomarkers predicts survival of pancreatic cancer patients with inoperable disease.Journal of gastrointestinal cancer · 2014Trial
- Phytochemical Profiling and Therapeutic Potential of Thyme (Food science & nutrition · 2024Review
- Novel prognostic scores based on serum ferritin/globulin ratio in patients with hepatocellular carcinoma.Translational cancer research · 2020Article
- Nutritional and non-nutritional factors associated with low birth weight in Sawula Town, Gamo Gofa Zone, Southern Ethiopia.BMC research notes · 2019Article
- Article
- Physiology of iron metabolism.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Review
- MR characterization of hepatic storage iron in transfusional iron overload.Journal of magnetic resonance imaging : JMRI · 2014Article
- The iron metallome in eukaryotic organisms.Metal ions in life sciences · 2013Article
- Cellular and mitochondrial iron homeostasis in vertebrates.Biochimica et biophysica acta · 2012Review
- Mammalian iron metabolism and its control by iron regulatory proteins.Biochimica et biophysica acta · 2012Review
- Iron metabolism: current facts and future directions.Biochemia medica · 2012Review
Corrections and comments
- Retraction · 2012-06-06Concerns/Issues about Data · Duplication of/in Image · Error in Image · Falsification/Fabrication of Image · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Ivana De Domeinco aka Ivana Frech has ORI Finding of misconduct: see https://ori.hhs.gov/content/case-summary-de-domenico-ivana
- Commented on by
- Retracted
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ferritin is a multisubunit protein that is responsible for storing and detoxifying cytosolic iron. Ferritin can be found in serum but is relatively iron poor. Serum ferritin occurs in iron overload disorders, in inflammation, and in the genetic disorder hyperferritinemia with cataracts. We show that ferritin secretion results when cellular ferritin synthesis occurs in the relative absence of free cytosolic iron. In yeast and mammalian cells, newly synthesized ferritin monomers can be translocated into the endoplasmic reticulum and transits through the secretory apparatus. Ferritin chains can be translocated into the endoplasmic reticulum in an in vitro translation and membrane insertion system. The insertion of ferritin monomers into the ER occurs under low-free-iron conditions, as iron will induce the assembly of ferritin. Secretion of ferritin chains provides a mechanism that limits ferritin nanocage assembly and ferritin-mediated iron sequestration in the absence of the translational inhibition of ferritin synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.