ArticleJournal of molecular biology2011
MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP.
Article in Journal of molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Motor Neuronopathy With Widespread Fasciculations in MCM3AP-Related Disorder: Clinical and Muscle MRI Insights.Journal of the peripheral nervous system : JPNS · 2026Article
- Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex-Lessons from Transcription-Coupled DNA Damages.International journal of molecular sciences · 2024Review
- Identification of a novel caspase cleavage motif AEAD.Virologica Sinica · 2024Article
- The Human TREX-2 Complex Interacts with Subunits of the ORC Complex.Doklady. Biochemistry and biophysics · 2023Article
- The Xmas-2 Protein of Drosophila melanogaster Undergoes Cleavage into Two Fragments.Doklady. Biochemistry and biophysics · 2023Article
- Recessive Charcot-Marie-Tooth and multiple sclerosis associated with a variant inBrain communications · 2019Article
- VRK2A is an A-type lamin-dependent nuclear envelope kinase that phosphorylates BAF.Molecular biology of the cell · 2017Article
- Control of mammalian gene expression by selective mRNA export.Nature reviews. Molecular cell biology · 2015Review
- GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.Nature communications · 2013Article
- Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export.Nucleic acids research · 2012Article
- The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus.PloS one · 2012Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
MCM3 acetylase (MCM3AP) and germinal-centre associated nuclear protein (GANP) are transcribed from the same locus and are therefore confused in databases because the MCM3 acetylase DNA sequence is contained entirely within the much larger GANP sequence and the entire MCM3AP sequence is identical to the carboxy terminus of GANP. Thus, the MCM3AP and GANP genes are read in the same reading frame and MCM3AP is an N-terminally truncated region of GANP. However, we show here that MCM3AP and GANP are different proteins, occupying different locations in the cell and transcribed from different promoters. Intriguingly, a promoter for MCM3AP lies within an intron of GANP. This report is an interesting example in nature of two separate gene products from the same locus that perform two entirely different functions in the cell. Therefore, to avoid further confusion, they should now be referred to as separate but overlapping genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.