ArticleDevelopmental biology2011
Transdifferentiation of tadpole pancreatic acinar cells to duct cells mediated by Notch and stromelysin-3.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Matrix Metalloproteinases and Their Inhibitors in Pulmonary Fibrosis: EMMPRIN/CD147 Comes into Play.International journal of molecular sciences · 2022Review
- Insufficiency of Thyroid Hormone in Frog Metamorphosis and the Role of Glucocorticoids.Frontiers in endocrinology · 2019Review
- Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis.Development genes and evolution · 2017Review
- Notch Signaling in Pancreatic Development.International journal of molecular sciences · 2015Review
- Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis.American journal of respiratory cell and molecular biology · 2015Review
- Thyroid hormone alleviates demyelination induced by cuprizone through its role in remyelination during the remission period.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Article
- Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.Developmental biology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The tadpole pancreas has differentiated acinar cells but an underdeveloped ductal system. At the climax of metamorphosis thyroid hormone (TH) induces the tadpole acinar cells to dedifferentiate to a progenitor state. After metamorphosis is complete the exocrine pancreas redifferentiates in the growing frog forming a typical vertebrate pancreas including a complex ductal system. A micro array analysis found that TH up regulates stromelysin 3 (ST3, matrix metalloproteinase 11) in the exocrine pancreas at metamorphic climax. Transgenic tadpoles were prepared with an elastase promoter driving either the ST3 gene or the constitutively active form of Notch (IC). Expression of the transgenes was controlled by the tetracycline system. A few days after either of these transgenes is activated by doxycycline the pancreatic acinar cells turn into duct-like cells. This transdetermination occurs without cell division since both acinar and ductal markers can be visualized transiently in the same cell. We propose that remodeling of the tadpole acinar cells is initiated when ST3 is up regulated by TH. Stromelysin-3 then cleaves and activates Notch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.