ArticleMedical oncology (Northwood, London, England)2012
Lung fluorescence imaging to evaluate tumor metastasis induced by AQP5 expression in murine model.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Aquaporin-5: from structure to function and dysfunction in cancer.Cellular and molecular life sciences : CMLS · 2016Review
- Over-expression of a poor prognostic marker in prostate cancer: AQP5 promotes cells growth and local invasion.World journal of surgical oncology · 2014Article
- Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our recent study, by up-regulation of AQP5 expression, showed enhanced proliferation and migration potential in lung cancer. However, so far none of the in vivo study of gene silencing of AQP5 has been tested. In this study, we tested roles of AQP5 on lung cancer metastasis potential by gene silencing of AQP5 in two lung cancer cell lines and tried to monitor lung metastases with EGFP marker. Lungs were imaged at different time points and allowed an accurate evaluation of tumor burden over time. Our results showed significantly decreased metastasis potential in AQP5 gene-silencing cells. Lung imaging confirmed the frequency of metastasis in mice. These data provide more evidence that AQP5 plays important roles in the metastasis potential of lung cancer. Lung fluorescence imaging provides rapid monitoring for tumor growth and metastasis, and it also offers quantitative and sensitive analysis of tumor growth and metastasis, compared to the traditional histology technique.
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Registered trials
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