ArticleBehavior genetics2011
Genetic covariation underlying reading, language and related measures in a sample selected for specific language impairment.
Article in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cross-Study Differences in the Etiology of Reading Comprehension: a Meta-Analytical Review of Twin Studies.Behavior genetics · 2017Pooled it
- Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds.Behavior genetics · 2017Article
- Examining Procedural Learning and Corticostriatal Pathways for Individual Differences in Language: Testing Endophenotypes ofLanguage, cognition and neuroscience · 2016Article
- Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes.Journal of neurodevelopmental disorders · 2016Article
- Genome-wide screening for DNA variants associated with reading and language traits.Genes, brain, and behavior · 2014Article
- Genome-wide association study of receptive language ability of 12-year-olds.Journal of speech, language, and hearing research : JSLHR · 2014Article
- Gene × gene interaction in shared etiology of autism and specific language impairment.Biological psychiatry · 2012Article
- Defining the genetic architecture of human developmental language impairment.Life sciences · 2012Review
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Authors and funding
9 authors.
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Abstract
Specific language impairment is a developmental language disorder characterized by failure to develop language normally in the absence of a specific cause. Previous twin studies have documented the heritability of reading and language measures as well as the genetic correlation between those measures. This paper presents results from an alternative to the classical twin designs by estimating heritability from extended pedigrees. These pedigrees were previously studied as part of series of molecular genetic studies of specific language impairment where the strongest genetic findings were with reading phenotypes rather than language despite selecting pedigrees based on language impairments. To explore the relationship between reading and language in these pedigrees, variance components estimates of heritability of reading and language measures were conducted showing general agreement with the twin literature, as were genetics correlations between reading and language. Phonological short-term memory, phonological awareness and auditory processing were evaluated as candidate mediators of the reading-language genetic correlations. Only phonological awareness showed significant genetic correlations with all reading measures and several language measures while phonological short-term memory and auditory processing did not.
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