Evidence map›Paper›PMID 21193839›Full record

ArticleCancer biology & therapy2011

A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors.

Kah Jing Lim, Savita Bisht, Eli E Bar, Anirban Maitra, Charles G Eberhart

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer biology & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
8.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 231 citations in OpenAlex.

  1. Review
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  4. New Curcumin Analogue (PAC) InhibitsAntibiotics (Basel, Switzerland) · 2025
    Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kah Jing LimGraduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Savita Bisht
Eli E Bar
Anirban Maitra
Charles G Eberhart
Johns Hopkins University · US

Funding

Zebrafish CoreP01CA134292 · NCI · JOHNS HOPKINS UNIVERSITY · PI LEACH, STEVEN D · 2009 to 2013
$7.4M
Hedgehog Inhibitors in Pancreas CancerR01CA113669 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAITRA, ANIRBAN · 2005 to 2014
$3.1M
Inhibiting Notch activity and brain tumor progression using Zen Sheng Ping (ZSP)R21AT003893 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI EBERHART, CHARLES G · 2008 to 2009
$451k
NCCIH NIH HHS R21 AT003893NCI NIH HHS P01 CA134292NCI NIH HHS R01 CA113669
6 · The paper itself

Abstract

Curcumin is a polyphenolic compound derived from the Indian spice turmeric. We used nanoparticle-encapsulated curcumin to treat medulloblastoma and glioblastoma cells. This formulation caused a dose-dependent decrease in growth of multiple brain tumor cell cultures, including the embryonal tumor derived lines DAOY and D283Med, and the glioblastoma neurosphere lines HSR-GBM1 and JHH-GBM14. The reductions in viable cell mass observed were associated with a combination of G(2)/M arrest and apoptotic induction. Curcumin also significantly decreased anchorage-independent clonogenic growth and reduced the CD133-positive stem-like population. Down-regulation of the insulin-like growth factor pathway in DAOY medulloblastoma cells was observed, providing one possible mechanism for the changes. Levels of STAT3 were also attenuated. Hedgehog signaling was blocked in DAOY cells but Notch signaling was not inhibited. Our data suggest that curcumin nanoparticles can inhibit malignant brain tumor growth through the modulation of cell proliferation, survival and stem cell phenotype.

Indexed as

NanocapsulesAC133 AntigenAntigens, CDAntineoplastic AgentsApoptosisCell Line, TumorCell ProliferationCurcuminDown-RegulationGlioblastomaGlycoproteinsHedgehog ProteinsHumansMedulloblastomaMitosisNeoplastic Stem CellsAC133 AntigenAntigens, CDAntineoplastic AgentsCurcuminGlycoproteinsHedgehog ProteinsNanocapsulesPeptidesPolymersPROM1 protein, humanReceptors, NotchSomatomedinsSTAT3 protein, humanSTAT3 Transcription Factor

Identifiers

PMID21193839
PMCPMC3087900
OpenAlexW2113518731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.