ArticleReproductive sciences (Thousand Oaks, Calif.)2011
Contractile response of human anterior vaginal muscularis in women with and without pelvic organ prolapse.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Smooth muscle cell plasticity in pelvic organ prolapse.Nature reviews. Urology · 2026Article
- Smooth muscle contribution to vaginal viscoelastic response.Journal of the mechanical behavior of biomedical materials · 2023Article
- Advances in vaginal bioengineering: Applications, techniques, and needs.Current research in physiology · 2023Review
- Role of fibulin-5 insufficiency and prolapse progression on murine vaginal biomechanical function.Scientific reports · 2021Article
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
- New Zealand white rabbit: a novel model for prolapse mesh implantation via a lumbar colpopexy.International urogynecology journal · 2020Article
- Impact of polypropylene prolapse mesh on vaginal smooth muscle in rhesus macaque.American journal of obstetrics and gynecology · 2019Article
- Smooth muscle regional contribution to vaginal wall function.Interface focus · 2019Article
- Extracellular matrix regenerative graft attenuates the negative impact of polypropylene prolapse mesh on vagina in rhesus macaque.American journal of obstetrics and gynecology · 2017Article
- In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.International journal of molecular medicine · 2016Article
- The impact of prolapse mesh on vaginal smooth muscle structure and function.BJOG : an international journal of obstetrics and gynaecology · 2016Article
- Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis.The journal of sexual medicine · 2013Article
- Vaginal degeneration following implantation of synthetic mesh with increased stiffness.BJOG : an international journal of obstetrics and gynaecology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The aim of this study was to compare the contractility of the anterior vaginal muscularis (AVM) from women with and without pelvic organ prolapse (POP). In vitro experiments were performed to measure the peak force generated in response to potassium chloride (KCl; 125 mmol/L) and phenylephrine by AVM tissue from women with and without POP. Cross-sectional areas and co-localization of α(1A) adrenergic receptor protein with smooth muscle α-actin in AVM strips were determined by histology and immunofluorescence, respectively. There were no differences in the mean amplitude of force generated in response to KCl normalized to either wet weight or muscle cross-sectional area (mN/mm(2)) between women with and without POP (P > .30). However, AVM from women with prolapse produced a significantly higher mean force to KCl normalized to total cross-sectional area compared to controls (P = .007). While the control samples demonstrated a consistent response to phenylephrine, there was no response to this stimulant generated by AVM tissue from women with POP. The proportion of co-localized α(1A) adrenergic receptors with smooth muscle α actin in AVM tissue was significantly less in women with POP compared to normal controls (P < .0001). Although there was significantly greater tissue stress generated by AVM from women with prolapse compared to controls, there were no differences in muscle stress. Absent response to phenylephrine by AVM from women with prolapse may be related to a lower expression of α(1A) adrenergic receptors in vaginal smooth muscle.
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Registered trials
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