ArticleMolecular endocrinology (Baltimore, Md.)2011
A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells.
Article in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Recent Advances in the Understanding of Gonadotrope Lineage Differentiation in the Developing Pituitary.Neuroendocrinology · 2025Review
- Paracrine FGF1 signaling directs pituitary architecture and size.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Role of Glucocorticoid Receptor in the Pathophysiology of Pituitary Corticotroph Adenomas.International journal of molecular sciences · 2022Review
- The Mechanisms Underlying Autonomous Adrenocorticotropic Hormone Secretion in Cushing's Disease.International journal of molecular sciences · 2020Review
- Maternal paraben exposure triggers childhood overweight development.Nature communications · 2020Article
- Pituitary cell translation and secretory capacities are enhanced cell autonomously by the transcription factor Creb3l2.Nature communications · 2019Article
- Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function.JCI insight · 2018Article
- Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats.International journal of obesity (2005) · 2018Article
- Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesity.FEBS letters · 2017Review
- Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer.Genes & development · 2017Article
- EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis.Journal of the Endocrine Society · 2017Article
- E2F1-mediated human POMC expression in ectopic Cushing's syndrome.Endocrine-related cancer · 2016Article
- The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.The Journal of experimental medicine · 2016Article
- Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III.Nature communications · 2015Article
- Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease.The Journal of clinical endocrinology and metabolism · 2015Article
- Enhancer-bound LDB1 regulates a corticotrope promoter-pausing repression program.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold.PLoS genetics · 2015Article
- Enhancer turnover and conserved regulatory function in vertebrate evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Evolution of transcriptional enhancers and animal diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cell-specific expression of the pituitary proopiomelanocortin (POMC) gene depends on the combination of tissue- and cell-restricted transcription factors such as Pitx1 and Tpit. These factors act on the proximal POMC promoter together with transcription factors that integrate inputs from signaling pathways. We now report the identification of an upstream enhancer in the POMC locus that is targeted by the same subset of transcription factors, except Pitx1. This enhancer located at -7 kb in the mouse POMC gene is highly dependent on Tpit for activity. Whereas Tpit requires Pitx1 for action on the promoter, it acts on the -7-kb enhancer as homodimers binding to a palindromic Tpit response element (TpitRE). Both half-sites of the TpitRE palindrome and Tpit homodimerization are required for activity. In vivo, the enhancer exhibits preferential activity in corticotrope cells of the anterior lobe whereas the promoter exhibits preference for intermediate lobe melanotropes. The enhancer is conserved among different species with the TpitRE palindrome localized at the center of conserved sequences. However, the mouse and human -7-kb enhancers do not exhibit conservation of hormone responsiveness and may differ in their relative importance for POMC expression. In summary, pituitary expression of the POMC gene relies on an upstream enhancer that complements the activity of the proximal promoter with Tpit as the major regulator of both regulatory regions.
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