ArticleEndocrinology2011
A novel functional role for the oocyte-specific transcription factor newborn ovary homeobox (NOBOX) during early embryonic development in cattle.
Article in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Platelet-rich plasma and folliculogenesis: a systematic mechanistic review and computational pathway analysis.Frontiers in reproductive health · 2026Pooled it
- Article
- Stage-, dose- and course-dependent disruption of mice fetal ovarian development following prenatal dexamethasone exposure.Journal of ovarian research · 2026Article
- Integrated analysis of lncRNA-miRNA-mRNA networks reveals stage-specific molecular regulation of oogenesis in Chinese alligator (Alligator sinensis).BMC genomics · 2026Article
- Agouti-signaling protein (ASIP) improves bovine in vitro matured oocyte developmental competence and modulates lipid content.Journal of assisted reproduction and genetics · 2025Article
- Molecular cloning of PRD-like homeobox genes expressed in bovine oocytes and early IVF embryos.BMC genomics · 2024Article
- Oviductal extracellular vesicles miRNA cargo varies in response to embryos and their quality.BMC genomics · 2024Article
- Association between polymorphisms inFrontiers in veterinary science · 2024Article
- The Role of BDNF, YBX1, CENPF, ZSCAN4, TEAD4, GLIS1 and USF1 in the Activation of the Embryonic Genome in Bovine Embryos.International journal of molecular sciences · 2023Review
- Toxic effect window of ovarian development in female offspring mice induced by prenatal prednisone exposure with different doses and time.Journal of ovarian research · 2023Article
- The Origin and Evolution of Bladder Cancer Stem Cells.Frontiers in cell and developmental biology · 2022Review
- Genome-Wide Association Study Provides Insights into Important Genes for Reproductive Traits in Nelore Cattle.Animals : an open access journal from MDPI · 2021Article
- Connecting links between genetic factors defining ovarian reserve and recurrent miscarriages.Journal of assisted reproduction and genetics · 2018Review
- Integrated Analysis of Quantitative Proteome and Transcriptional Profiles Reveals the Dynamic Function of Maternally Expressed Proteins After Parthenogenetic Activation of Buffalo Oocyte.Molecular & cellular proteomics : MCP · 2018Article
- Oocyte related factors impacting on embryo quality: relevance forAnimal reproduction · 2018Article
- The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?Stem cell reviews and reports · 2016Review
- CHD1 Regulates Deposition of Histone Variant H3.3 During Bovine Early Embryonic Development.Biology of reproduction · 2016Article
- Article
- Evidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin.Biology of reproduction · 2015Article
- Maternal control of early embryogenesis in mammals.Reproduction, fertility, and development · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Newborn ovary homeobox (NOBOX) is an oocyte-specific transcription factor essential for folliculogenesis and expression of many germ cell-specific genes in mice. Here we report the characterization of the bovine NOBOX gene and its role in early embryogenesis. The cloned cDNA for bovine NOBOX contains an open reading frame encoding a protein of 500 amino acids with a conserved homeodomain. mRNA for NOBOX is preferentially expressed in ovaries and undetectable by RT-PCR in somatic tissues examined. NOBOX protein is present in oocytes throughout folliculogenesis. NOBOX is expressed in a stage-specific manner during oocyte maturation and early embryonic development and of maternal origin. Knockdown of NOBOX in early embryos using small interfering RNA demonstrated that NOBOX is required for embryonic development to the blastocyst stage. Depletion of NOBOX in early embryos caused significant down-regulation of genes associated with transcriptional regulation, signal transduction, and cell cycle regulation during embryonic genome activation. In addition, NOBOX depletion in early embryos reduced expression of pluripotency genes (POU5F1/OCT4 and NANOG) and number of inner cell mass cells in embryos that reached the blastocyst stage. This study demonstrates that NOBOX is an essential maternal-derived transcription factor during bovine early embryogenesis, which functions in regulation of embryonic genome activation, pluripotency gene expression, and blastocyst cell allocation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.