ArticleThe Journal of pediatrics2011
Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure.
Article in The Journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease.The Cochrane database of systematic reviews · 2021Pooled it
- Safety and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in children with SCD: a V114-023 (PNEU-SICKLE) study.Blood advances · 2023Trial
- Trial
- Clinical Features and Outcomes of Pneumococcal Bacteremia in Children With Sickle Cell Disease in the Pneumococcal Conjugate Vaccine Era.Pediatric blood & cancer · 2025Article
- Serotype specific pneumococcal vaccine effectiveness in children with sickle cell disease: A two-decade analysis.Vaccine · 2025Article
- Pneumococcal infections in children with sickle cell disease before and after pneumococcal conjugate vaccines.Blood advances · 2023Article
- Frequency of serious bacterial infection among febrile sickle cell disease children in the era of the conjugate vaccine: A retrospective study.International journal of pediatrics & adolescent medicine · 2022Article
- Incidence of Acute Chest Syndrome in Children With Sickle Cell Disease Following Implementation of the 13-Valent Pneumococcal Conjugate Vaccine in France.JAMA network open · 2022Article
- Assessment of humoral immunity and nutritionally essential trace elements in steady-state sickle cell disease Nigerian children before and afterBlood science (Baltimore, Md.) · 2022Article
- Monocyte HLA-DR Expression to Monitor Immune Response and Potential Infection Risks Following Vaso-Occlusive Crises in Patients with Sickle Cell Anemia.Mediterranean journal of hematology and infectious diseases · 2022Article
- Article
- Review
- Small molecule therapeutics to treat the β-globinopathies.Current opinion in hematology · 2020Review
- Sickle cell disease: a comprehensive program of care from birth.Hematology. American Society of Hematology. Education Program · 2019Review
- Incidence of invasive Haemophilus influenzae infections in children with sickle cell disease.Pediatric blood & cancer · 2019Article
- Sickle Cell Disease and Infections in High- and Low-Income Countries.Mediterranean journal of hematology and infectious diseases · 2019Review
- Evaluation of newborn sickle cell screening programme in England: 2010-2016.Archives of disease in childhood · 2018Article
- Review
- Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data.Scientific reports · 2017Article
- Current Standards of Care and Long Term Outcomes for Thalassemia and Sickle Cell Disease.Advances in experimental medicine and biology · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Invasive pneumococcal disease (IPD) in children with sickle cell disease has decreased with prophylactic penicillin, pneumococcal polysaccharide vaccine, and pneumococcal protein-conjugate vaccine usage. We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.