Trial reportHormones and behavior2011
The effects of oral micronized progesterone on smoked cocaine self-administration in women.
Trial report in Hormones and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The influence of sex and reproductive cycle on cocaine-induced behavioral and neurobiological alterations: a review.Experimental brain research · 2022Pooled it
- Exogenous progesterone for cannabis withdrawal in women: Feasibility trial of a novel multimodal methodology.Pharmacology, biochemistry, and behavior · 2019Trial
- The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: impact of gender and cue type.Psychoneuroendocrinology · 2013Trial
- Endocrine modulation of stimulant use: bidirectional interactions within the hypothalamic-pituitary-gonadal axis.Frontiers in behavioral neuroscience · 2026Review
- Clinical neuropharmacology of cocaine reinforcement: A narrative review of human laboratory self-administration studies.Journal of the experimental analysis of behavior · 2022Review
- Consideration of sex as a biological variable in the translation of pharmacotherapy for stress-associated drug seeking.Neurobiology of stress · 2021Review
- Role of Exogenous Progesterone in the Treatment of Men and Women with Substance Use Disorders: A Narrative Review.CNS drugs · 2018Review
- Sex differences, gender and addiction.Journal of neuroscience research · 2017Review
- Sex and menstrual cycle effects on chronic oral cocaine self-administration in rhesus monkeys: Effects of a nondrug alternative reward.Psychopharmacology · 2016Article
- Evaluation of the "Pipeline" for Development of Medications for Cocaine Use Disorder: A Review of Translational Preclinical, Human Laboratory, and Clinical Trial Research.Pharmacological reviews · 2016Review
- Effects of levodopa-carbidopa-entacapone and smoked cocaine on facial affect recognition in cocaine smokers.Journal of psychopharmacology (Oxford, England) · 2016Article
- Determining menstrual phase in human biobehavioral research: A review with recommendations.Experimental and clinical psychopharmacology · 2016Review
- Butyrylcholinesterase levels and subjective effects of smoked cocaine in healthy cocaine users.The American journal of drug and alcohol abuse · 2015Article
- Progesterone Reduces Cocaine Use in Postpartum Women with a Cocaine Use Disorder: A Randomized,Double-Blind Study.The lancet. Psychiatry · 2014Article
- Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- Estrogen receptors mediate estradiol's effect on sensitization and CPP to cocaine in female rats: role of contextual cues.Hormones and behavior · 2014Article
- Estrous cycle and HIV-1 Tat protein influence cocaine-conditioned place preference and induced locomotion of female mice.Current HIV research · 2014Article
- Impact of pubertal and adult estradiol treatments on cocaine self-administration.Hormones and behavior · 2013Article
- Increased impulsive choice for saccharin during PCP withdrawal in female monkeys: influence of menstrual cycle phase.Psychopharmacology · 2013Article
- Effects of menstrual cycle phase on cocaine self-administration in rhesus macaques.Hormones and behavior · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
There are currently no FDA-approved pharmacotherapies for cocaine abuse. Converging preclinical and clinical evidence indicates that progesterone may have potential as a treatment for cocaine-abusing women, who represent a growing portion of cocaine users. We have previously shown that oral progesterone reduced the positive subjective effects of cocaine in female cocaine users during the follicular phase of the menstrual cycle, when endogenous progesterone levels were low. To extend these findings, the present study assessed the effects of oral progesterone (150 mg BID) administered during the follicular phase on smoked cocaine self-administration in women relative to the normal follicular and luteal phases. Healthy, non-treatment seeking female cocaine smokers (N=10) underwent three 4-day inpatient stays, during: 1) a normal follicular phase; 2) a normal luteal phase; and 3) a follicular phase when oral progesterone was administered. During each stay, participants completed 4 self-administration sessions in which they first smoked a "sample" dose of cocaine (0, 12, 25 or 50 mg) and then had 5 opportunities at 14-minute intervals to self-administer that dose at a cost of $5 per dose. Expected cocaine dose effects on self-administration, subjective effects, and cardiovascular effects were observed. However, there was no effect of oral progesterone administration or menstrual cycle phase on cocaine self-administration. Thus, oral progesterone was not effective in reducing cocaine use in women under the current conditions. However, based on previous literature, further research assessing the role of oral progesterone for the treatment of cocaine dependence in women is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.