ArticleBMC neurology2010
Mood after stroke: a case control study of biochemical, neuro-imaging and socio-economic risk factors for major depression in stroke survivors.
Article in BMC neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Homocysteine level at the acute stage of ischemic stroke as a biomarker of poststroke depression: A systematic review and meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis.Neuropsychology review · 2017Pooled it
- Association of Microvascular Dysfunction With Late-Life Depression: A Systematic Review and Meta-analysis.JAMA psychiatry · 2017Pooled it
- Factors associated with post-stroke depression one month after discharge among older patients based on Health Ecology Theory: a retrospective cross-sectional study of consecutive cases.Frontiers in psychiatry · 2026Article
- Association between systemic immune-inflammation index at admission and post-stroke depression in patients with acute ischemic stroke.Frontiers in neurology · 2025Article
- Association of Vitamin B12 and Polymorphism ofNeuropsychiatric disease and treatment · 2024Article
- Higher homocysteine and fibrinogen are associated with early-onset post-stroke depression in patients with acute ischemic stroke.Frontiers in psychiatry · 2024Article
- Determinants of post-stroke depression among stroke survivors at University of Gondar Hospital, Northwest Ethiopia: a case-control study.BMC neurology · 2022Article
- Elevated monocyte-to-HDL cholesterol ratio predicts post-stroke depression.Frontiers in psychiatry · 2022Article
- Association of homocysteine and polymorphism of methylenetetrahydrofolate reductase with early-onset post stroke depression.Frontiers in nutrition · 2022Article
- Depressed Mood after Stroke: Predictive Factors at Six Months Follow-Up.International journal of environmental research and public health · 2020Observational
- The validity and reliability of the PHQ-9 in screening for post-stroke depression.BMC psychiatry · 2020Article
- Assessment of the Progression of Poststroke Depression in Ischemic Stroke Patients Using the Patient Health Questionnaire-9.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Post-stroke depression inhibits improvement in activities of daily living in patients in a convalescent rehabilitation ward.Journal of physical therapy science · 2016Article
- Monoamine neurotransmitters and fibroblast growth factor-2 in the brains of rats with post-stroke depression.Experimental and therapeutic medicine · 2014Article
- The correlates and course of depression in patients with lacunar stroke: results from the Secondary Prevention of Small Subcortical Strokes (SPS3) study.Cerebrovascular diseases (Basel, Switzerland) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThough vascular factors may be important in the aetiology of late-life depression, it is not clear whether they have a major effect on the risk of depression after a stroke. We investigated the relationship between physiological, biochemical, neuro-imaging and socio-economic factors and late-phase post-stroke depression in a cross-sectional case-control study.
methodsPeople living at home at least 9 months after a stroke were interviewed using a structured proforma. Depression was diagnosed according to DSM-IV criteria, together with a Montgomery Asberg (MADRS) score >17. Stroke survivors of similar age and functional status but without symptoms of, or recent treatment for, depression and with MADRS score <7, were recruited as controls.
resultsStroke survivors with depression were more likely than controls to have been smokers, to have had hypertension or peripheral arterial disease, and to have had more than one stroke or multiple discrete brainscan lesions. In univariate analysis they had significantly higher blood pressure, lower Mini-Mental State (MMSE) scores, higher serum homocysteine and lower folate levels, as well as more extensive white matter and basal ganglia changes on brainscan. In logistic regression, previous hypertension (OR 3.4), peripheral vascular disease (OR 4.7), number of strokes (OR 2), MMSE score (OR 0.76) and basal ganglia changes (OR 2.2), were independently associated with depression.
conclusionThese results suggest that patients with hypertension, hyperhomocysteinaemia and other factors associated with cerebral small vessel disease, may be more susceptible to post-stroke depression. Future intervention trials should focus on such high risk groups.
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