SynthesisWorld journal of pediatrics : WJP2011
Fever of unknown origin in children: a systematic review.
Synthesis in World journal of pediatrics : WJP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- Prolonged Fever in Children: An Inpatient Diagnostic Framework for Infections in Australia.Journal of paediatrics and child health · 2025Guideline
- A double-blind comparative study of Chinese herbal medicine Jinlianqingre Effervescent Tablets in combination with conventional therapy for the treatment of uncomplicated hand, foot, and mouth disease.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Trial
- Human herpes viruses are associated with classic fever of unknown origin (FUO) in Beijing patients.PloS one · 2014Trial
- Diagnostic value of basic and extended procedures in pediatric fever of unknown origin - results of a nation-wide surveillance study.Molecular and cellular pediatrics · 2026Article
- Assessment of childhood disease patterns in outpatient settings: a retrospective study from 2016 to 2020.Frontiers in pediatrics · 2026Article
- The etiological spectrum of pediatric FUO and clinical management of PFAPA/SURF: a ten-year retrospective study.Frontiers in immunology · 2026Article
- FDG-PET/MR in paediatric pyrexia of unknown origin: early detection of Takayasu arteritis-a single-centre experience.Frontiers in pediatrics · 2026Article
- Assessment and Management of Pain and Fever in Pediatric Patients in the Emergency Setting: A Proposed Flowchart for the Triage Nurse.Children (Basel, Switzerland) · 2025Article
- Comparison of Brucellosis and Rickettsiosis in Children: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Clinical and metagenomic characteristics of lymphadenopathy related to fever of unknown origin in children.Pediatric research · 2024Article
- Droplet digital PCR aids in the diagnosis of children with fever of unknown origin --A typical case report.Heliyon · 2024Article
- Nuclear Medicine Imaging Tools in Fever of Unknown Origin: Time for a Revisit and Appropriate Use Criteria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Retrospective Analysis of Fever in Pediatric Age: Our Experience over the Last 5 Years.Children (Basel, Switzerland) · 2024Article
- Article
- Fever management in children and insights into fever of unknown origin: a survey among Italian pediatricians.Frontiers in pediatrics · 2024Article
- Update on Fever of Unknown Origin in Children: Focus on Etiologies and Clinical Approach.Children (Basel, Switzerland) · 2023Review
- Cytomegalovirus viremia in an 11-year-old child with sickle cell disease manifested only with fever: a case report.Annals of medicine and surgery (2012) · 2023Article
- Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study.Journal of epidemiology and global health · 2023Article
- Article
- Optimal use of the FDG-PET/CT in the diagnostic process of fever of unknown origin (FUO): a comprehensive review.Japanese journal of radiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundthere are no previous systematic reviews of published pediatric case series describing the etiology of fever of unknown origin (FUO). The purpose of collecting these data is to determine the etiologies for children with FUO in both developing and developed countries.
methodsthe database Ovid Medline R (1950 to August 2009 week 4) and Ovid Embase (1980 to 2010 week 2) were used to conduct the search. Studies in any language were included if they provided the diagnosis in a series of 10 or more children with FUO. The diagnosis of each child at the time of publication of the study was recorded.
resultsthere were 18 studies that met the inclusion criteria, describing 1638 children. The diagnosis at the time of publication was malignancy for 93 children (6%), collagen vascular disease for 150 (9%), miscellaneous non-infectious conditions for 179 (11%), infection for 832 (51%), and no diagnosis for 384 (23%). There were 491 bacterial infections (59% of all infections) with common diagnoses being brucellosis, tuberculosis, and typhoid fever in developing countries, osteomyelitis, tuberculosis, and Bartonellosis in developed countries, and urinary tract infections in both. For children with no diagnosis after investigations, most had fever that ultimately resolved with no sequelae.
conclusionsabout half of FUOs in published case series are ultimately shown to be due to infections with collagen vascular disease and malignancy also being common diagnoses. However, there is such a wide variety of possibilities that investigations should primarily be driven by the clinical story.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.