ArticleSurgery today2011
Sinusoidal obstruction syndrome compromises liver regeneration in patients undergoing two-stage hepatectomy with portal vein embolization.
Article in Surgery today, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Predictive Factors for Hypertrophy of the Future Liver Remnant After Portal Vein Embolization: A Systematic Review.Cardiovascular and interventional radiology · 2021Pooled it
- Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis.Annals of surgical oncology · 2012Pooled it
- Evaluation of liver regeneration and post-hepatectomy liver failure after hemihepatectomy in patients with hepatocellular carcinoma.Bioscience reports · 2019Trial
- Preoperative Chemotherapy with Gemcitabine and Cisplatin for Biliary Tract Cancer Does Not Affect Liver Regeneration Induced by Portal Vein Embolization.Annals of surgical oncology · 2026Article
- Review
- Prognostic assessment of resected colorectal liver metastases integrating pathological features, RAS mutation and Immunoscore.The journal of pathology. Clinical research · 2021Article
- The effect of preoperative chemotherapy on liver regeneration after portal vein embolization/ligation or liver resection in patients with colorectal liver metastasis: a systematic review protocol.Systematic reviews · 2020Article
- Splenic enlargement induced by preoperative chemotherapy is a useful indicator for predicting liver regeneration after resection for colorectal liver metastases.World journal of surgical oncology · 2020Article
- Review
- Oxidative stress induced by portal vein embolization in fatty liver: Experimental study of a nonalcoholic steatohepatitis model.Biomedical reports · 2018Article
- Update on Liver Failure Following Hepatic Resection: Strategies for Prediction and Avoidance of Post-operative Liver Insufficiency.Journal of clinical and translational hepatology · 2018Review
- Evaluation of patients who underwent percutaneous transhepatic portal vein embolisation by Tc-99m GSA scintigraphy.Polish journal of radiology · 2018Article
- Chemotherapy-induced liver injury in metastatic colorectal cancer: about 48 cases.The Pan African medical journal · 2018Article
- Article
- Defining Post Hepatectomy Liver Insufficiency: Where do We stand?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Review
- Post-hepatectomy liver failure in patients with colorectal liver metastases.Surgery today · 2015Review
- Remnant growth rate after portal vein embolization is a good early predictor of post-hepatectomy liver failure.Journal of the American College of Surgeons · 2014Article
- Prolonged portal triad clamping increases postoperative sepsis after major hepatectomy in patients with sinusoidal obstruction syndrome and/or steatohepatitis.World journal of surgery · 2012Article
- Total resection of the right hepatic vein drainage area with the aid of three-dimensional computed tomography.Surgery today · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSeveral factors have been reported to affect liver regeneration after portal vein embolization (PVE); however, the effect of sinusoidal obstruction syndrome (SOS) has not been evaluated. Therefore, we assessed the effect of SOS on liver regeneration after PVE in patients with multiple bilobar colorectal liver metastases scheduled to undergo two-stage hepatectomy (TSH) combined with PVE.
methodsThe subjects of this study were 78 patients prospectively scheduled to undergo TSH between December 1996 and August 2009. Archived formalin-fixed, paraffin-embedded nontumoral tissue samples were collected from the 1st- and 2nd-stage hepatectomies in 42 and 45 patients, respectively, and SOS and steatohepatitis were diagnosed pathologically. We analyzed the clinicopathological variables affecting liver regeneration after PVE.
resultsSinusoidal obstruction syndrome was diagnosed in 11 (26.2%) and 20 patients (44.4%) at the time of the 1st- and 2nd-stage hepatectomy, respectively. Patients with SOS at the 1st-stage hepatectomy had a significantly lower hypertrophy ratio of the future remnant liver (FRL) after PVE than patients without SOS (16.8 ± 24.0 vs 55.6 ± 32.5; P < 0.001). Multivariate logistic regression analysis revealed that SOS was an independent factor predicting lower FRL hypertrophy after PVE (Δ% FRL <20: hazard ratio 31.7, 95% confidence interval 2.84-355.12; P = 0.005). The incidence of postoperative transient liver failure after the 2nd-stage hepatectomy in patients presenting with SOS was higher than that in those without SOS, but the difference did not reach significance (25.0% vs 4.0%; P = 0.052). Steatohepatitis was confirmed at the 1st- and 2nd-stage hepatectomy in 6 (14.3%) and 3 (6.7%) patients, respectively.
conclusionSinusoidal obstruction syndrome inhibits FRL hypertrophy after PVE and induces postoperative liver failure. Therefore, an alternative strategy is needed to perform TSH safely in the presence of SOS.
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