ArticleCellular and molecular neurobiology2011
The effects of Tag-1 on the maturation of mouse cerebellar granule neurons.
Article in Cellular and molecular neurobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Genome binding properties of Zic transcription factors underlie their changing functions during neuronal maturation.BMC biology · 2024Article
- Genome binding properties of Zic transcription factors underlie their changing functions during neuronal maturation.bioRxiv : the preprint server for biology · 2024Article
- Ataxia telangiectasia alters the ApoB and reelin pathway.Neurogenetics · 2018Article
- BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4.Molecular biology of the cell · 2018Article
- Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation.Frontiers in molecular neuroscience · 2017Review
- Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The cell adhesion molecule Tag-1 is highly expressed in immature cerebellar granule neurons (CGNs) during axonogenesis and is down-regulated prior to onset of radial migration. However, its precise role(s) during development of mammalian CGNs has been unclear. Here we studied the effects of anti-Tag-1 function blocking antibodies on the development of mouse CGNs in primary cell culture and in situ. Interfering antibodies inhibited axon formation by mouse CGNs in both cell cultures and in cerebellar slices. Effects on axon extension in cell cultures were observed under conditions of homotypic cell-cell contact, consistent with inhibition of cell adhesion activity. Further, when used as a substratum Tag-1 protein strongly stimulated neurite outgrowth by CGNs. Antagonism of Tag-1 also enhanced CGN migration in modified Boyden chamber assays. Radial migration was inhibited by Tag-1 antibodies in cerebellar slices, possibly reflecting a block in early CGN maturation in situ. These findings are consistent with a regulatory role for Tag-1 in axon emergence as well as migratory behavior by developing mouse CGNs.
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Registered trials
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