ArticleThe Journal of investigative dermatology2011
Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections.
Article in The Journal of investigative dermatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
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- Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Complete Genome Sequences of Bioluminescent Staphylococcus aureus Strains Xen31 and Xen36, Derived from Two Clinical Isolates.Microbiology resource announcements · 2023Article
- The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection.Microbiology spectrum · 2022Article
- Expression of Staphylococcal Virulence Genes In Situ in Human Skin and Soft Tissue Infections.Antibiotics (Basel, Switzerland) · 2022Article
- Gene Expression Profile Analyses of the Skin Response of Balb/c-Nu Mice Model Injected byClinical, cosmetic and investigational dermatology · 2022Article
- Inhibition of planktonic growth and biofilm formation ofFrontiers in microbiology · 2022Article
- Comparative Study of Two-Dimensional (2D) vs. Three-Dimensional (3D) Organotypic Kertatinocyte-Fibroblast Skin Models forInternational journal of molecular sciences · 2021Article
- Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease.The Journal of clinical investigation · 2021Article
- Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates.Antibiotics (Basel, Switzerland) · 2020Review
- Research Techniques Made Simple: Mouse Bacterial Skin Infection Models for Immunity Research.The Journal of investigative dermatology · 2020Article
- Interleukin-1β and tumor necrosis factor are essential in controlling an experimental orthopedic implant-associated infection.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Staphylococcus aureus Fatty Acid Kinase FakA Modulates Pathogenesis during Skin Infection via Proteases.Infection and immunity · 2020Article
- Preclinical Models and Methodologies for Monitoring Staphylococcus aureus Infections Using Noninvasive Optical Imaging.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections.Scientific reports · 2019Article
- Clonal Vγ6Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1α release.The Journal of allergy and clinical immunology · 2019Article
- Control ofInfection and immunity · 2019Article
- Propofol specifically suppresses IL-1β secretion but increases bacterial survival in Staphylococcus aureus-infected RAW264.7 cells.Molecular and cellular biochemistry · 2018Article
- Immune and Inflammatory Reponses toCurrent dermatology reports · 2018Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Staphylococcus aureus skin infections represent a significant public health threat because of the emergence of antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA). As greater understanding of protective immune responses and more effective antimicrobial therapies are needed, a S. aureus skin wound infection model was developed in which full-thickness scalpel cuts on the backs of mice were infected with a bioluminescent S. aureus (methicillin sensitive) or USA300 community-acquired MRSA strain and in vivo imaging was used to noninvasively monitor the bacterial burden. In addition, the infection-induced inflammatory response was quantified using in vivo fluorescence imaging of LysEGFP mice. Using this model, we found that both IL-1α and IL-1β contributed to host defense during a wound infection, whereas IL-1β was more critical during an intradermal S. aureus infection. Furthermore, treatment of a USA300 MRSA skin infection with retapamulin ointment resulted in up to 85-fold reduction in bacterial burden and a 53% decrease in infection-induced inflammation. In contrast, mupirocin ointment had minimal clinical activity against this USA300 strain, resulting in only a 2-fold reduction in bacterial burden. Taken together, this S. aureus wound infection model provides a valuable preclinical screening method to investigate cutaneous immune responses and the efficacy of topical antimicrobial therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.