ReviewCell cycle (Georgetown, Tex.)2011
Substrate-specific regulation of ubiquitination by the anaphase-promoting complex.
Review in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- The dual role of whole-genome duplication: biological mechanisms, functional consequences, and detection advances.Acta biochimica et biophysica Sinica · 2025Review
- Overcoming ABCB1 mediated multidrug resistance in castration resistant prostate cancer.Cell death & disease · 2024Article
- Overcoming ABCB1 mediated multidrug resistance in castration resistant prostate cancer.Research square · 2024Article
- Inhibition of Mps1 kinase enhances taxanes efficacy in castration resistant prostate cancer.Cell death & disease · 2022Article
- Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C.Nature communications · 2019Article
- Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.Plant physiology · 2018Article
- Endoreplication: The Good, the Bad, and the Ugly.Trends in cell biology · 2018Review
- PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.Cell cycle (Georgetown, Tex.) · 2018Article
- APC/CG3 (Bethesda, Md.) · 2017Article
- Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.Cell reports · 2015Article
- The histone acetyltransferase component TRRAP is targeted for destruction during the cell cycle.Oncogene · 2014Article
- Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.Nature cell biology · 2013Article
- Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer.Molecular biology reports · 2013Article
- SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.Nature cell biology · 2013Article
- Endoreplication and polyploidy: insights into development and disease.Development (Cambridge, England) · 2013Review
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- Regulation of APC/C-Cdh1 and its function in neuronal survival.Molecular neurobiology · 2012Review
- Flipping the switch from g1 to s phase with e3 ubiquitin ligases.Genes & cancer · 2012Article
- Control of MCAK degradation and removal from centromeres.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Processive ubiquitin chain formation by the anaphase-promoting complex.Seminars in cell & developmental biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By orchestrating the sequential degradation of a large number of cell cycle regulators, the ubiquitin ligase anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The correct timing of APC/C-dependent substrate degradation, a critical feature of progression through mitosis, was long known to be controlled by mechanisms targeting the core APC/C-machinery. Recent experiments, however, have revealed an important contribution of substrate-specific regulation of the APC/C to achieve accurate cell division. In this perspective, we describe different mechanisms of substrate-specific APC/C-regulation and discuss their importance for cell division.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.