ArticleCell cycle (Georgetown, Tex.)2011
Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-δ.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Early human trophoblast development: from morphology to function.Cellular and molecular life sciences : CMLS · 2022Review
- Plausibility of trophoblastic-like regulation of cancer tissue.Cancer management and research · 2019Article
- A historical review of blastocyst implantation research.Biology of reproduction · 2018Review
- Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent.Oncotarget · 2015Article
- Bisphenol a influences blastocyst implantation via regulating integrin β3 and trophinin expression levels.International journal of clinical and experimental medicine · 2015Article
- Intracellular Ca2+ signaling and preimplantation development.Advances in experimental medicine and biology · 2015Review
- Cell signaling in trophoblast-uterine communication.The International journal of developmental biology · 2014Review
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- Enhancement of mouse sperm motility by trophinin-binding peptide.Reproductive biology and endocrinology : RB&E · 2012Article
- Life and death responses to trophinin-mediated adhesion during blastocyst implantation.Cell cycle (Georgetown, Tex.) · 2011Article
- Placental protein 13: An important biological protein in preeclampsia.Journal of circulating biomarkersReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trophinin is an intrinsic membrane protein expressed in trophectoderm cells of embryos and in uterine epithelial cells. Trophinin potentially mediates apical cell adhesion at human embryo implantation sites through trophinin-trophinin binding in these two cell types. Trophinin-mediated cell adhesion activates trophectoderm cells for invasion, whereas the effect of adhesion on maternal side is not known. We show that addition of GWRQ peptide, a previously established peptide that mimics trophinin-mediated cell adhesion, to human endometrial epithelial cells expressing trophinin induces their apoptosis. FAS involvement was excluded, as GWRQ did not bind to FAS, and FAS knockdown did not alter GWRQ-induced apoptosis. Immunoblotting analyses of protein kinases revealed an elevation of PKC-d protein in GWRQ-bound endometrial epithelial cells. In the absence of GWRQ, PKC-d associated with trophinin and remained cytoplasmic, but after GWRQ binding to the trophinin extracellular domain, PKC-d became tyrosine phosphorylated, dissociated from trophinin, and entered the nucleus. In PKC-d knockdown endometrial cells, GWRQ did not induce apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.