ArticleBiophysical journal2011
Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 66 citations in OpenAlex.
- Biomechanical anticoagulation by spherical platelets in extracorporeal systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- FimH-mannose noncovalent bonds survive minutes to hours under force.Biophysical journal · 2024Article
- A computational investigation of occlusive arterial thrombosis.Biomechanics and modeling in mechanobiology · 2024Article
- Molecular mechanisms of catch bonds and their implications for platelet hemostasis.Biophysical reviews · 2023Review
- A Computational Investigation of Occlusive Arterial Thrombosis.Research square · 2023Article
- Receptor-Ligand Binding: Effect of Mechanical Factors.International journal of molecular sciences · 2023Review
- Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes.Acta pharmaceutica Sinica. B · 2022Article
- Inhibition of post-surgery tumour recurrence via a sprayable chemo-immunotherapy gel releasing PD-L1 antibody and platelet-derived small EVs.Journal of nanobiotechnology · 2022Article
- Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation.Journal of the Royal Society, Interface · 2021Article
- Tissue mechanics in stem cell fate, development, and cancer.Developmental cell · 2021Review
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- Physical forces regulating hemostasis and thrombosis: Vessels, cells, and molecules in illustrated review.Research and practice in thrombosis and haemostasis · 2021Review
- Clot Permeability, Agonist Transport, and Platelet Binding Kinetics in Arterial Thrombosis.Biophysical journal · 2020Article
- Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine.Stroke and vascular neurology · 2020Review
- Dynamic bonds and their roles in mechanosensing.Current opinion in chemical biology · 2019Review
- Regulatory element in fibrin triggers tension-activated transition from catch to slip bonds.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mechano-redox control of integrin de-adhesion.eLife · 2018Article
- Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins.Molecular biology of the cell · 2018Article
- Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow.Journal of the Royal Society, Interface · 2017Article
- Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The regulated ability of integrin αIIbβ3 to bind fibrinogen plays a crucial role in platelet aggregation, adhesion, and hemostasis. Employing an optical-trap-based electronic force clamp, we studied the thermodynamics and kinetics of αIIbβ3-fibrinogen bond formation and dissociation under constant unbinding forces, mimicking the forces of physiologic blood shear on a thrombus. The distribution of bond lifetimes was bimodal, indicating that the αIIbβ3-fibrinogen complex exists in two bound states with different mechanical stability. The αIIbβ3 antagonist, abciximab, inhibited binding without affecting the unbinding kinetics, whereas Mn²(+) biased the αIIbβ3-fibrinogen complex to the strong bound state with reduced off-rate. The average bond lifetimes decreased exponentially with increasing pulling force from ∼5 pN to 50 pN, suggesting that in this force range the αIIbβ3-fibrinogen interactions are classical slip bonds. We found no evidence for catch bonds, which is consistent with the known lack of shear-enhanced platelet adhesion on fibrinogen-coated surfaces. Taken together, these data provide important quantitative and qualitative characteristics of αIIbβ3-fibrinogen binding and unbinding that underlie the dynamics of platelet adhesion and aggregation in blood flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.