ArticleAnalytical chemistry2011
Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode arrays.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
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- Selective Detection of Acetylcholine against Choline and In Vivo Measurement in the Mouse Brain Using the Micropipet-Supported Liquid/Liquid Interface Electrode.ACS measurement science au · 2025Article
- Exploiting Microelectrode Geometry for Comprehensive Detection of Individual Exocytosis Events at Single Cells.ACS sensors · 2023Article
- Direct Acquisition of the Gap Height of Biological Tissue-Electronic Chemical Sensor Interfaces.Angewandte Chemie (International ed. in English) · 2022Article
- Carbon microelectrodes with customized shapes for neurotransmitter detection: A review.Analytica chimica acta · 2022Review
- Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells.Analytical chemistry · 2022Article
- Dual-Channel Electrochemical Measurements Reveal Rapid Adenosine is Localized in Brain Slices.ACS chemical neuroscience · 2022Article
- Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities.Micromachines · 2021Review
- Evaluation of electrochemical methods for tonic dopamine detectionTrends in analytical chemistry : TRAC · 2020Article
- Nanoelectrochemistry in the study of single-cell signaling.Analytical and bioanalytical chemistry · 2020Review
- Nano-engineering the material structure of preferentially oriented nano-graphitic carbon for making high-performance electrochemical micro-sensors.Scientific reports · 2020Article
- Recent advances in fast-scan cyclic voltammetry.The Analyst · 2020Review
- Review-Recent Advances in Nanosensors Built with Pre-Pulled Glass Nanopipettes and Their Applications in Chemical and Biological Sensing.Journal of the Electrochemical Society · 2020Article
- Optical Tracking of Nanometer-Scale Cellular Membrane Deformation Associated with Single Vesicle Release.ACS sensors · 2019Article
- Electrodeposited Gold on Carbon-Fiber Microelectrodes for Enhancing Amperometric Detection of Dopamine Release from Pheochromocytoma Cells.Analytical chemistry · 2018Article
- Single Synaptic Observation of Cholinergic Neurotransmission on Living Neurons: Concentration and Dynamics.Journal of the American Chemical Society · 2018Article
- Fast-Scan Cyclic Voltammetry: Chemical Sensing in the Brain and Beyond.Analytical chemistry · 2018Review
- Electrochemical measurement of quantal exocytosis using microchips.Pflugers Archiv : European journal of physiology · 2018Review
- Single cell amperometry reveals curcuminoids modulate the release of neurotransmitters during exocytosis from PC12 cells.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2016Article
- Electrochemical Analysis of Neurotransmitters.Annual review of analytical chemistry (Palo Alto, Calif.) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Carbon-fiber-microelectrode arrays (MEAs) have been utilized to electrochemically image neurochemical secretion from individual pheochromocytoma (PC12) cells. Dopamine release events were electrochemically monitored from seven different locations on single PC12 cells using alternately constant-potential amperometry and fast-scan cyclic voltammetry (FSCV). Cyclic voltammetry, when compared to amperometry, can provide excellent chemical resolution; however, spatial and temporal resolution are both compromised. The spatial and temporal resolution of these two methods have been quantitatively compared and the differences explained using models of molecular diffusion at the nanogap between the electrode and the cell. A numerical simulation of the molecular flux reveals that the diffusion of dopamine molecules and electrochemical reactions both play important roles in the temporal resolution of electrochemical imaging. The simulation also reveals that the diffusion and electrode potential cause the differences in signal crosstalk between electrodes when comparing amperometry and FSCV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.