Evidence map›Paper›PMID 21190074›Full record

ArticleAIDS and behavior2012

Concurrent partnerships, acute infection and HIV epidemic dynamics among young adults in Zimbabwe.

Steven M Goodreau, Susan Cassels, Danuta Kasprzyk, Daniel E Montaño, April Greek, Martina Morris

Abstract read
In one paragraph

Article in AIDS and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. A Review of Network Models for HIV Spread.Journal of acquired immune deficiency syndromes (1999) · 2025
    Pooled it
  2. Concurrent partnerships and HIV: an inconvenient truth.Journal of the International AIDS Society · 2011
    Pooled it
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Steven M GoodreauDepartment of Anthropology, University of Washington, Seattle, USA. goodreau@u.washington.edu
Susan Cassels
Danuta Kasprzyk
Daniel E Montaño
April Greek
Martina Morris
Battelle · USUniversity of Washington · USSeattle University · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Judith Tsui · 1988 to 2026
$104.9M
ZIMBABWE--COMMUNITY INTERVENTION TO REDUCE HIV/STD RISKU10MH061544 · NIMH · BATTELLE CENTERS/PUB HLTH RES &EVALUATN · PI KASPRZYK, DANUTA · 2000 to 2006
$10.3M
Methods and Data CoreR24HD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI MAR, CORINNE M · 2002 to 2016
$9.3M
Multi-component, Targeted HIV Prevention for sub-Saharan Africa: PreventionRxR01AI083034 · NIAID · UNIVERSITY OF WASHINGTON · PI CELUM, CONNIE L · 2009 to 2012
$4.3M
Statistical Methods for Network EpidemiologyR01HD068395 · NICHD · UNIVERSITY OF WASHINGTON · PI MORRIS, WANDA MARTINA · 2011 to 2015
$3.0M
Modeling HIV and STD in Drug User and Social NetworksR01DA012831 · NIDA · UNIVERSITY OF WASHINGTON · PI MORRIS, WANDA MARTINA · 2001 to 2005
$2.6M
Quantifying HIV Transmission Risk in Sex/Drug NetworksR01HD041877 · NICHD · UNIVERSITY OF WASHINGTON · PI MORRIS, WANDA MARTINA · 2002 to 2006
$1.0M
Alcohol, Risky Behavior, and HIV/AIDS in ZimbabweR21AA014802 · NIAAA · BATTELLE CENTERS/PUB HLTH RES &EVALUATN · PI CUBBINS, LISA ANN · 2004 to 2006
$939k
Migration to Urban Slums, Sexual Networks, and HIV in GhanaR00HD057553 · NICHD · UNIVERSITY OF WASHINGTON · PI CASSELS, SUSAN LYNN · 2010 to 2012
$700k
Migration to Urban Slums, Sexual Networks, and HIV in GhanaK99HD057553 · NICHD · UNIVERSITY OF WASHINGTON · PI CASSELS, SUSAN LYNN · 2008 to 2009
$176k
NIAAA NIH HHS R21 AA014802NIAAA NIH HHS R2I-AA014802NIAID NIH HHS P30 AI027757NIAID NIH HHS P30-AI27757NIAID NIH HHS R01 AI083034NICHD NIH HHS K99 HD057553NICHD NIH HHS K99-HD057553NICHD NIH HHS R00 HD057553NICHD NIH HHS R01 HD041877NICHD NIH HHS R01-HD041877NICHD NIH HHS R01 HD068395NICHD NIH HHS R24 HD042828NIDA NIH HHS R01 DA012831NIDA NIH HHS R01-DA12831NIMH NIH HHS U10 MH061544NIMH NIH HHS U10-MH061544
6 · The paper itself

Abstract

This paper explores the roles of acute infection and concurrent partnerships in HIV transmission dynamics among young adults in Zimbabwe using realistic representations of the partnership network and all published estimates of stage-specific infectivity. We use dynamic exponential random graph models to estimate partnership network parameters from an empirical study of sexual behavior and drive a stochastic simulation of HIV transmission through this dynamic network. Our simulated networks match observed frequencies and durations of short- and long-term partnerships, with concurrency patterns specific to gender and partnership type. Our findings suggest that, at current behavior levels, the epidemic cannot be sustained in this population without both concurrency and acute infection; removing either brings transmission below the threshold for persistence. With both present, we estimate 20-25% of transmissions stem from acute-stage infections, 30-50% from chronic-stage, and 30-45% from AIDS-stage. The impact of acute infection is strongly moderated by concurrency. Reducing this impact by reducing concurrency could potentially end the current HIV epidemic in Zimbabwe.

Indexed as

Sexual PartnersAcute DiseaseAdolescentAdultEpidemicsFemaleHIV SeropositivityHumansMaleModels, TheoreticalSex DistributionSexual BehaviorSurveys and QuestionnairesYoung AdultZimbabwe

Identifiers

PMID21190074
PMCPMC3394592
OpenAlexW2152845061

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.