ArticleKorean journal of pediatrics2010
Electrocardiography as an early cardiac screening test in children with mitochondrial disease.
Article in Korean journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Cardiac complications in inherited mitochondrial diseases.Heart failure reviews · 2021Review
- Bedaquiline inhibits the yeast and human mitochondrial ATP synthases.Communications biology · 2020Article
- Systematic review and meta-analysis of cardiac involvement in mitochondrial myopathy.Neurology. Genetics · 2019Article
- Article
- Chronic maternal hypercortisolemia in late gestation alters fetal cardiac function at birth.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Characteristic cardiac phenotypes are detected by cardiovascular magnetic resonance in patients with different clinical phenotypes and genotypes of mitochondrial myopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2015Article
- Diagnosis and treatment of mitochondrial myopathies.Annals of medicine · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate myocardial conductivity to understand cardiac involvement in patients with mitochondrial disease.
methodsWe performed retrospective study on fifty-seven nonspecific mitochondrial encephalopathy patients with no clinical cardiac manifestations. The patients were diagnosed with mitochondrial respiratory chain complex defects through biochemical enzyme assays of muscle tissue. We performed standard 12-lead electrocardiography (ECG) on all patients.
resultsECG abnormalities were observed in 30 patients (52.6%). Prolongation of the QTc interval (>440 ms) was seen in 19 patients (33.3%), widening of the corrected QRS interval in 15 (26.3%), and bundle branch block in four (7.0%). Atrioventricular block, premature atrial contraction and premature ventricular contraction were seen in two patients each (3.5%) and Wolff-Parkinson-White syndrome in one patient (1.8%).
conclusionGiven this finding, we recommend active screening with ECG in patients with mitochondrial disease even in patients without obvious cardiac manifestation.
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Registered trials
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