Evidence map›Paper›PMID 21189476›Full record

ArticleNature reviews. Microbiology2011

Genetic control of Candida albicans biofilm development.

Jonathan S Finkel, Aaron P Mitchell

Abstract read
In one paragraph

Article in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 307 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
307citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

307 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review on the implication of Candida in peri-implantitis.International journal of implant dentistry · 2021
    Pooled it
  2. Article
  3. Zerumbone combined with antimicrobial photodynamic inactivation reduces growth of Candida albicans biofilms and modulates virulence gene expression.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  4. Article
  5. Morphotype-specific susceptibility toMicrobiology spectrum · 2026
    Article
  6. Article
  7. Voriconazole Activity AgainstMolecules (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Cell Wall Proteome ofPathogens (Basel, Switzerland) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Fungal Biofilm: An Overview of the Latest Nano-Strategies.Antibiotics (Basel, Switzerland) · 2025
    Review
  19. Review
  20. Article

247 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jonathan S FinkelDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
Aaron P Mitchell

Funding

GENETIC CONTROL OF C. ALBICANS BIOFILM FORMATIONR01AI067703 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MITCHELL, AARON P · 2006 to 2014
$3.2M
The Regulation of Biofilm Formation in Fungal PathogensF32AI085521 · NIAID · CARNEGIE-MELLON UNIVERSITY · PI FINKEL, JONATHAN SEWELL · 2009 to 2010
$93k
NIAID NIH HHS F32 AI085521NIAID NIH HHS R01 AI067703
6 · The paper itself

Abstract

Candida species cause frequent infections owing to their ability to form biofilms - surface-associated microbial communities - primarily on implanted medical devices. Increasingly, mechanistic studies have identified the gene products that participate directly in the development of Candida albicans biofilms, as well as the regulatory circuitry and networks that control their expression and activity. These studies have uncovered new mechanisms and signals that govern C. albicans biofilm development and associated drug resistance, thus providing biological insight and therapeutic foresight.

Indexed as

BiofilmsCandida albicansEnvironmentExtracellular MatrixGenes, FungalQuorum Sensing

Identifiers

PMID21189476
PMCPMC3891587

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.