ArticleMolecules (Basel, Switzerland)2010
Antimalarial activity of methanolic leaf extract of Piper betle L.
Article in Molecules (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 107 citations in OpenAlex.
- Anthelmintic effects of Areca catechu L. (Arecaceae) and Piper betle L. (Piperaceae) combination on adult Haemonchus spp.: a scanning electron microscopy study.BMC veterinary research · 2025Article
- Effect of selected Indonesian plants on Giardia intestinalis in an experimental in vitro model.BMC complementary medicine and therapies · 2025Article
- Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice.BMC complementary medicine and therapies · 2023Article
- Article
- Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes.Journal of cellular and molecular medicine · 2022Review
- Natural Antioxidants as Additional Weapons in the Fight against Malarial Parasite.Current topics in medicinal chemistry · 2022Review
- Article
- Potential of Piper spp. as a source of new compounds for the leishmaniases treatment.Parasitology research · 2021Review
- Review
- Novel Amides Derivative with Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2021Article
- Antimalarial Activity of Hydromethanolic Crude Extract and Chloroform Fraction ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Evaluation of the Antimalarial Activity of the Leaf Latex ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Antimalarial Activity of the Leaf Latex ofJournal of tropical medicine · 2020Article
- Antimalarial Activities of Hydromethanolic Crude Extract and Chloroform Fraction ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds.Journal of tropical medicine · 2020Article
- Medico-Religious Plants Employed in Mauritius: A Survey Among Hindu Priests.Journal of religion and health · 2019Article
- Review
- BornylInternational journal of molecular sciences · 2018Article
- The Effect of BornylInternational journal of molecular sciences · 2018Article
- Antimalarial and antiplasmodial activity of husk extract and fractions of Zea mays.Pharmaceutical biology · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05) schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.