ArticleProceedings of the National Academy of Sciences of the United States of America2011
Immature T-cell clustering and efficient differentiation require the polarity protein Scribble.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM.The FEBS journal · 2023Article
- E-cadherin in developing murine T cells controls spindle alignment and progression through β-selection.Science advances · 2023Article
- The Scribble Complex PDZ Proteins in Immune Cell Polarities.Journal of immunology research · 2020Review
- Influence of Scribble polarity complex on hematopoiesis and leukemia - a matter of where, when and how.Oncotarget · 2018Article
- Diverging impact of cell fate determinants Scrib and Llgl1 on adhesion and migration of hematopoietic stem cells.Journal of cancer research and clinical oncology · 2018Article
- The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function.Leukemia · 2018Article
- TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.Scientific reports · 2017Article
- Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.The Journal of biological chemistry · 2016Article
- Scribble acts as an oncogene in Eμ-myc-driven lymphoma.Oncogene · 2016Article
- Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.Immunology and cell biology · 2016Article
- Asymmetric Cell Division in T Lymphocyte Fate Diversification.Trends in immunology · 2015Review
- Asymmetric cell division during T cell development controls downstream fate.The Journal of cell biology · 2015Article
- Pseudorabies virus triggers glycoprotein gE-mediated ERK1/2 activation and ERK1/2-dependent migratory behavior in T cells.Journal of virology · 2015Article
- Polarized cells, polarized views: asymmetric cell division in hematopoietic cells.Frontiers in immunology · 2014Review
- Polarity gene discs large homolog 1 regulates the generation of memory T cells.European journal of immunology · 2013Article
- Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.Nature communications · 2013Article
- Polarity and lymphocyte fate determination.Current opinion in cell biology · 2012Review
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Authors and funding
3 authors.
Funding
Abstract
T-cell polarization is required for cell migration and cell-cell interactions, cellular behaviors crucial for lymphocyte differentiation. Despite expression of the epithelial polarity network in T cells, neither its contribution to thymocyte polarity nor its requirement during development is known. We report here that depletion of the polarity protein Scribble in hematopoietic progenitor cells results in inefficient T-cell development characterized by a partial developmental block during the early double-negative (DN) stage of differentiation. Scribble-depleted hematopoietic progenitor cells exhibit a delayed transition into late CD44(lo/-)CD25(+) DN3 cells, evidenced by the accumulation of early CD44(int)CD25(+) DN3 cells. As a consequence, a limited cellular expansion and a reduced frequency of intracellular T-cell receptor β-positive DN3 cells are observed among Scribble-deficient differentiating T cells. Moreover, whereas purified Scribble-depleted DN2 and DN3 cells do not exhibit compromised spontaneous motility, T-cell clustering and prolonged homotypic interactions among such cells are reduced. This deficiency correlates with a lack of polarization of the integrin LFA-1 during T-cell migration or on the initiation of T-cell-T-cell interactions. Scribble is therefore a critical contributor to the clustering of immature T cells, an event shown here to be necessary for efficient developmental progression.
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