ArticleMolecular and cellular biology2011
HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- HEB collaborates with TCR signaling to upregulatebioRxiv : the preprint server for biology · 2025Article
- A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.Genes & development · 2025Article
- The Function of E2A in B-Cell Development.Advances in experimental medicine and biology · 2024Review
- Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells.Frontiers in immunology · 2023Review
- High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD.Scientific reports · 2022Article
- MonoallelicFrontiers in immunology · 2022Article
- Transcriptional Regulation of Early T-Lymphocyte Development in Thymus.Frontiers in immunology · 2022Review
- The E-Id Axis Instructs Adaptive Versus Innate Lineage Cell Fate Choice and Instructs Regulatory T Cell Differentiation.Frontiers in immunology · 2022Review
- Helix-Loop-Helix Proteins in Adaptive Immune Development.Frontiers in immunology · 2022Review
- Signaling networks controlling ID and E protein activity in T cell differentiation and function.Frontiers in immunology · 2022Review
- Regulation of the Signal-Dependent E Protein HEBAlt Through a YYY Motif Is Required for Progression Through T Cell Development.Frontiers in immunology · 2022Article
- Editorial: Molecular switches of the immune system: The E-protein/Id axis in hematopoietic development and function.Frontiers in immunology · 2022Article
- Functional definition of a transcription factor hierarchy regulating T cell lineage commitment.Science advances · 2020Article
- Programming for T-lymphocyte fates: modularity and mechanisms.Genes & development · 2019Review
- Dynamical Analysis of the Regulatory Network Controlling Natural Killer Cells Differentiation.Frontiers in physiology · 2018Article
- HEB is required for the specification of fetal IL-17-producing γδ T cells.Nature communications · 2017Article
- Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.The Journal of clinical investigation · 2016Article
- Transcription of RORγt in developing Th17 cells is regulated by E-proteins.Mucosal immunology · 2014Article
- HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.Clinical & developmental immunology · 2012Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early thymocytes possess multilineage potential, which is progressively restricted as cells transit through the double-negative stages of T-cell development. DN1 cells retain the ability to become natural killer cells, dendritic cells, B cells, and myeloid cells as well as T cells, but these options are lost by the DN3 stage. The Notch1 signaling pathway is indispensable for initiation of the T-cell lineage and inhibitory for the B-cell lineage, but the regulatory mechanisms by which the T-cell fate is locked in are largely undefined. Previously, we discovered that the E-protein transcription factor HEBAlt promoted T-cell specification. Here, we report that HEB(-/-) T-cell precursors have compromised Notch1 function and lose T-cell potential. Moreover, reconstituting HEB(-/-) precursors with Notch1 activity enforced fidelity to the T-cell fate. However, instead of becoming B cells, HEB(-/-) DN3 cells adopted a DN1-like phenotype and could be induced to differentiate into thymic NK cells. HEB(-/-) DN1-like cells retained GATA3 and Id2 expression but had lower levels of the Bcl11b gene, a Notch target gene. Therefore, our studies have revealed a new set of interactions between HEB, Notch1, and GATA3 that regulate the T-cell fate choice in developing thymocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.