ArticleMolecular and cellular biology2011
Characterization of the core elements of the NF-κB signaling pathway of the sea anemone Nematostella vectensis.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 72 citations in OpenAlex.
- Algae-specific immune modulation influences responses to heat and pathogen challenge in a symbiotic coral.Science advances · 2026Article
- c-JUN controls microbial colonization via selective phagocytosis in the sea anemone Nematostella.Nature communications · 2026Article
- NF-κB: A Diverse and Multifunctional Transcription Factor in Holozoans.Molecular biology and evolution · 2026Review
- The Influence of Symbiont Identity on the Proteomic and Metabolomic Responses of the Model Cnidarian Aiptasia to Thermal Stress.Environmental microbiology · 2025Article
- Updated single cell reference atlas for the starlet anemone Nematostella vectensis.Frontiers in zoology · 2024Article
- A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation.The Journal of biological chemistry · 2023Article
- Starvation decreases immunity and immune regulatory factor NF-κB in the starlet sea anemone Nematostella vectensis.Communications biology · 2023Article
- A Conserved Core Region of the Scaffold NEMO is Essential for Signal-induced Conformational Change and Liquid-liquid Phase Separation.bioRxiv : the preprint server for biology · 2023Article
- An innate ability: How do basal invertebrates manage their chronic exposure to microbes?PLoS pathogens · 2022Article
- Microbiota mediated plasticity promotes thermal adaptation in the sea anemone Nematostella vectensis.Nature communications · 2022Article
- The cyclic dinucleotide 2'3'-cGAMP induces a broad antibacterial and antiviral response in the sea anemoneProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor.Communications biology · 2021Article
- Cnidarian Pattern Recognition Receptor Repertoires Reflect Both Phylogeny and Life History Traits.Frontiers in immunology · 2021Article
- Looking Down on NF-κB.Molecular and cellular biology · 2020Review
- Diel patterning in the bacterial community associated with the sea anemoneEcology and evolution · 2019Article
- NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB.Cancers · 2019Review
- Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching.Scientific reports · 2017Article
- Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review).International journal of oncology · 2015Review
- Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Molecular cell · 2015Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The sea anemone Nematostella vectensis is the leading developmental and genomic model for the phylum Cnidaria, which includes anemones, hydras, jellyfish, and corals. In insects and vertebrates, the NF-κB pathway is required for cellular and organismal responses to various stresses, including pathogens and chemicals, as well as for several developmental processes. Herein, we have characterized proteins that comprise the core NF-κB pathway in Nematostella, including homologs of NF-κB, IκB, Bcl-3, and IκB kinase (IKK). We show that N. vectensis NF-κB (Nv-NF-κB) can bind to κB sites and activate transcription of reporter genes containing multimeric κB sites or the Nv-IκB promoter. Both Nv-IκB and Nv-Bcl-3 interact with Nv-NF-κB and block its ability to activate reporter gene expression. Nv-IKK is most similar to human IKKε/TBK kinases and, in vitro, can phosphorylate Ser47 of Nv-IκB. Nv-NF-κB is expressed in a subset of ectodermal cells in juvenile and adult Nematostella anemones. A bioinformatic analysis suggests that homologs of many mammalian NF-κB target genes are targets for Nv-NF-κB, including genes involved in apoptosis and responses to organic compounds and endogenous stimuli. These results indicate that NF-κB pathway proteins in Nematostella are similar to their vertebrate homologs, and these results also provide a framework for understanding the evolutionary origins of NF-κB signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.