ArticleReproductive biology and endocrinology : RB&E2010
Digit ratios by computer-assisted analysis confirm lack of anatomical evidence of prenatal androgen exposure in clinical phenotypes of polycystic ovary syndrome.
Article in Reproductive biology and endocrinology : RB&E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between 2D:4D Digit Ratio and Polycystic Ovary Syndrome: A Systematic Review.American journal of human biology : the official journal of the Human Biology Council · 2026Pooled it
- Comparison of acne vulgaris patients and healthy controls in terms of autistic features and 2D:4D ratio.International journal of developmental disabilities · 2024Article
- Systematical assessment of digit ratio in a female masculinization disease: polycystic ovary syndrome.Frontiers in endocrinology · 2023Article
- Variation among human populations in endometriosis and PCOS A test of the inverse comorbidity model.Evolution, medicine, and public health · 2021Review
- The association between second to fourth digit ratio, reproductive and general health among women: findings from an Israeli pregnancy cohort.Scientific reports · 2020Article
- Female digit length ratio (2D:4D) and time-to-pregnancy.Human reproduction (Oxford, England) · 2016Article
- Translational Insight Into Polycystic Ovary Syndrome (PCOS) From Female Monkeys with PCOS-like Traits.Current pharmaceutical design · 2016Review
- Intrauterine environment and polycystic ovary syndrome.Seminars in reproductive medicine · 2014Review
- Nonhuman primate models of polycystic ovary syndrome.Molecular and cellular endocrinology · 2013Review
- Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood.Fertility and sterility · 2013Review
- Early-to-mid gestation fetal testosterone increases right hand 2D:4D finger length ratio in polycystic ovary syndrome-like monkeys.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundWe recently showed that women with four clinical phenotypes of polycystic ovary syndrome (PCOS) do not demonstrate anatomical evidence of elevated prenatal androgen exposure as judged by a lower ratio of the index (2D) to ring (4D) finger. However, those findings conflicted with a previous study where women with PCOS had lower right hand 2D:4D compared to healthy female controls. Both these studies used Vernier calipers to measure finger lengths--a method recently shown to be less reliable at obtaining finger length measurements than computer-assisted analysis.
methodsNinety-six women diagnosed with PCOS according to the 2003 Rotterdam criteria had their finger lengths measured with computer-assisted analysis. Participants were categorized into four recognized phenotypes of PCOS and their 2D:4D compared to healthy female controls (n = 48) and men (n = 50).
resultsDigit ratios assessed by computer-assisted analysis in women with PCOS did not differ from female controls, but were significantly lower in men. When subjects were stratified by PCOS phenotype, 2D:4D did not differ among phenotypes or when compared to female controls.
conclusionComputer-assisted measurements validated that digit ratios of women with PCOS do not show anatomical evidence of increased prenatal androgen exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.