ReviewClinical reviews in allergy & immunology2013
The clinical significance of anti-beta-1 adrenergic receptor autoantibodies in cardiac disease.
Review in Clinical reviews in allergy & immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Relevance of Trypanothione Reductase Inhibitors onOxidative medicine and cellular longevity · 2018Pooled it
- Pharmacokinetics and Safety of Single Intravenous Doses of JNJ-54452840, an Anti-β1-Adrenergic Receptor Antibody Cyclopeptide, in Healthy Male Japanese and Caucasian Participants.Clinical pharmacokinetics · 2016Trial
- Alternative splicing remodeling and splicing factor regulatory networks define immune-associated molecular heterogeneity in dilated cardiomyopathy.Frontiers in bioinformatics · 2026Article
- [Lack of correlation for anti-β1 autoantibodies and cardioelectric disorders in chagas cardiomyopathy].Archivos de cardiologia de Mexico · 2023Article
- Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models.Clinical science (London, England : 1979) · 2023Article
- Compensatory Upregulation of Anti-Beta-Adrenergic Receptor Antibody Levels Might Prevent Heart Failure Presentation in Pediatric Myocarditis.Frontiers in pediatrics · 2022Article
- The Role of Autoantibodies in Arrhythmogenesis.Current cardiology reports · 2020Review
- Autoantibodies against MAging · 2020Article
- Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism.International journal of molecular sciences · 2020Review
- Diagnostic and prognostic value of autoantibodies against βExperimental and therapeutic medicine · 2020Article
- Lowered anti-beta1 adrenergic receptor antibody concentrations may have prognostic significance in acute coronary syndrome.Scientific reports · 2019Article
- Article
- Transcriptome Profiling Reveals PHLDA1 as a Novel Molecular Marker for Ischemic Cardiomyopathy.Journal of molecular neuroscience : MN · 2018Article
- The Contribution of Autoantibodies to Inflammatory Cardiovascular Pathology.Frontiers in immunology · 2018Review
- Beta-1-Adrenergic Receptor Antibodies in Acute Coronary Syndrome: Is Less Sometimes More?Frontiers in cardiovascular medicine · 2018Article
- βScientific reports · 2017Article
- β1-Adrenergic Receptor Contains Multiple IAFrontiers in immunology · 2017Article
- Autoimmunity in 2013.Clinical reviews in allergy & immunology · 2014Review
- The autoimmune side of heart and lung diseases.Clinical reviews in allergy & immunology · 2013Review
- Autoimmune heart disease: role of sex hormones and autoantibodies in disease pathogenesis.Expert review of clinical immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune response against myocardial antigens is evident in numerous heart diseases. Both the induction of an autoimmune response and the pathogenesis of autoimmune heart diseases are not fully understood. The humoral immune response may play an important role via induction of cardiomyocyte apoptosis, alteration of myocardial mechanical and electrophysiological functions, and activation of the complement system and cell-mediated cytotoxicity. Anti-β-1 adrenergic receptor antibodies appear to contribute to the pathogenesis of dilated cardiomyopathy, heart failure, and Chagas disease. Herein, we review the current knowledge relating to anti-β-1 adrenergic receptor antibodies: their potential role in heart diseases and the potential benefits of a targeted therapy against their apparently destructive effects. Patients with dilated cardiomyopathy with circulating stimulatory anti-β-1 adrenergic receptor autoantibodies are probably at a higher risk for adverse outcome and should be treated with adrenergic receptor antagonists, and possibly with immunotherapy. Further research is required to determine which patients will gain additional clinical benefits from anti-autoantibody-targeted therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.