ReviewClinical reviews in allergy & immunology2011
Genetics and immunopathogenesis of IgA nephropathy.
Review in Clinical reviews in allergy & immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Pathological sub-analysis of a multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy versus steroid pulse monotherapy in patients with immunoglobulin A nephropathy.Clinical and experimental nephrology · 2016Trial
- SOCS1 improves abnormal IgA galactosylation in IgA nephropathy by regulating the TLR9/MyD88 pathway.Immunologic research · 2025Article
- LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications.Clinical and experimental medicine · 2025Review
- Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study.International journal of molecular sciences · 2023Article
- Causal effects between gut microbiota and IgA nephropathy: a bidirectional Mendelian randomization study.Frontiers in cellular and infection microbiology · 2023Article
- The mucosal immune system and IgA nephropathy.Seminars in immunopathology · 2021Review
- SARS-CoV-2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms.Molecular systems biology · 2021Article
- The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients.Frontiers in immunology · 2021Article
- The Role of Immune Modulation in Pathogenesis of IgA Nephropathy.Frontiers in medicine · 2020Review
- Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity.BMC nephrology · 2018Article
- HLA and kidney disease: from associations to mechanisms.Nature reviews. Nephrology · 2018Review
- Hydroxychloroquine alleviates persistent proteinuria in IgA nephropathy.International urology and nephrology · 2017Article
- Immunoglobulin A nephropathy: a pathophysiology view.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- Combined Oral and Intravenous Immunization Stimulates Strong IgA Responses in Both Systemic and Mucosal Compartments.PloS one · 2016Article
- Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy.Journal of immunology research · 2016Article
- Salivary Microbiota Associated with Immunoglobulin A Nephropathy.Microbial ecology · 2015Article
- Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation.The Journal of biological chemistry · 2015Article
- Study of correlation between polymorphism of ST6GALNAC2 and susceptibility to IgA nephropathy.Experimental and therapeutic medicine · 2015Article
- Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers.Proteomics. Clinical applications · 2013Review
- Pathogenesis of IgA nephropathy.Nature reviews. Nephrology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The hallmark of IgAN is underglycosylation in the hinge region of IgA1. Increasing evidence supports the underglycosylated IgA-containing immune-complex including IgG antibodies against the glycans of the hinge region of IgA1 are key factors for mesangial deposition and then trigger inflammation and glomerular injury. The polymeric IgA is produced after aberrant mucosal IgA response. The displacement of mucosal B cells to systemic lymphoid organs and bone marrow may arise from abnormal trafficking of lymphocytes along the mucosa-bone marrow axis involving changes of chemokines and adhesion molecules. This review will summarize the works on the genetics, the mucosal and systemic IgA immune response, mechanism of underglycosylation of IgA1, and the pathological effect of mesangial IgA deposition in IgAN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.