ArticleJournal of natural medicines2011
Simultaneous quantification of marker components in Ojeok-san by HPLC-DAD.
Article in Journal of natural medicines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Acute Administration of Ojeok-san Ameliorates Pain-like Behaviors in Pre-Clinical Models of Inflammatory Bowel Diseases.Nutrients · 2023Article
- Bioactive Chemical Constituents and Pharmacological Activities of Ponciri Fructus.Molecules (Basel, Switzerland) · 2022Review
- Ojeok-san ameliorates visceral and somatic nociception in a mouse model of colitis induced colorectal cancer.PloS one · 2022Article
- Simultaneous determination of six active components in traditional herbal medicine 'Oyaksungisan' by HPLC-DAD.Journal of natural medicines · 2012Article
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Authors and funding
5 authors.
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Abstract
A systematic high-performance liquid chromatography-diode array detection (HPLC-DAD) method was developed for the rapid, accurate, and simultaneous quantification of eight marker compounds, paeoniflorin, 6-gingerol, decursin, glycyrrhizin, cinnamic acid, hesperidin, poncirin and magnolol, in Ojeok-san, a traditional Korean herbal medicine. These compounds were separated in less than 50 min using a Dionex C(18) column with a gradient elution system of water and methanol at a flow rate of 1 ml/min. All calibration curve of standard components showed excellent linearity (R(2) > 0.9922). Limits of detection (LOD) and limits of quantification (LOQ) ranged from 0.01 to 0.11 μg/ml and 0.03 to 0.34 μg/ml, respectively. The relative standard deviations (RSDs) of data of the intra- and inter-day experiments were less than 2.15 and 2.60%, respectively. The accuracy of recovery test ranged from 94.27 to 107.68% with RSD values 0.15-3.61%. The results of validation showed that the HPLC method was stable and very accurate for the quantification of eight marker components in Ojeok-san.
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