ArticleBiomechanics and modeling in mechanobiology2011
Computational modeling of growth: systemic and pulmonary hypertension in the heart.
Article in Biomechanics and modeling in mechanobiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 99 citations in OpenAlex.
- A modelling study of right ventricular growth with valvular regurgitation.Biomechanics and modeling in mechanobiology · 2026Article
- A unified finite element framework for cardiac growth and remodeling in mitral regurgitation incorporating fiber reorientation and baroreflex.Acta biomaterialia · 2026Article
- Astrocytes in white matter respond to tensile cues during cortical folding: a numerical study.bioRxiv : the preprint server for biology · 2025Article
- Multiscale Kinematic Growth Coupled With Mechanosensitive Systems Biology in Open-Source Software.Journal of biomechanical engineering · 2025Article
- Synergistic biophysics and machine learning modeling to rapidly predict cardiac growth probability.Computers in biology and medicine · 2025Article
- Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease.Annals of biomedical engineering · 2024Article
- Guidelines for mechanistic modeling and analysis in cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2024Review
- Insight to motor clutch model for sensing of ECM residual strain.Mechanobiology in medicine · 2023Article
- Article
- Computational models of ventricular mechanics and adaptation in response to right-ventricular pressure overload.Frontiers in physiology · 2022Review
- Data-driven computational models of ventricular-arterial hemodynamics in pediatric pulmonary arterial hypertension.Frontiers in physiology · 2022Article
- Plasticity and Enzymatic Degradation Coupled With Volumetric Growth in Pulmonary Hypertension Progression.Journal of biomechanical engineering · 2021Article
- Multiscale simulations of left ventricular growth and remodeling.Biophysical reviews · 2021Review
- Right ventricular myocardial mechanics: Multi-modal deformation, microstructure, modeling, and comparison to the left ventricle.Acta biomaterialia · 2021Article
- Characterization of Exercise-Induced Myocardium Growth Using Finite Element Modeling and Bayesian Optimization.Frontiers in physiology · 2021Article
- The Geometry of Incompatibility in Growing Soft Tissues: Theory and Numerical Characterization.Journal of the mechanics and physics of solids · 2021Article
- Mechanical stimuli for left ventricular growth during pressure overload.Experimental mechanics · 2021Article
- Computational models of cardiac hypertrophy.Progress in biophysics and molecular biology · 2021Review
- Predictions of hypertrophy and its regression in response to pressure overload.Biomechanics and modeling in mechanobiology · 2020Article
- Computational modeling of cardiac growth and remodeling in pressure overloaded hearts-Linking microstructure to organ phenotype.Acta biomaterialia · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We introduce a novel constitutive model for growing soft biological tissue and study its performance in two characteristic cases of mechanically induced wall thickening of the heart. We adopt the concept of an incompatible growth configuration introducing the multiplicative decomposition of the deformation gradient into an elastic and a growth part. The key feature of the model is the definition of the evolution equation for the growth tensor which we motivate by pressure-overload-induced sarcomerogenesis. In response to the deposition of sarcomere units on the molecular level, the individual heart muscle cells increase in diameter, and the wall of the heart becomes progressively thicker. We present the underlying constitutive equations and their algorithmic implementation within an implicit nonlinear finite element framework. To demonstrate the features of the proposed approach, we study two classical growth phenomena in the heart: left and right ventricular wall thickening in response to systemic and pulmonary hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.